CT evaluation of the resectability of gastric cancer postchemotherapy (Journal article)

Gossios, K./ Tsianos, E. V./ Nicolson, V./ Bamias, A./ Cunningham, D./ Husband, J.

BACKGROUND: To determine the accuracy of CT in the postchemotherapy assessment of resectability of gastric cancer. METHODS: Thirty patients deemed to have unresectable gastric cancer on CT were studied. This was verified at laparotomy in 10 of these patients. Following initial assessment, all received three to eight cycles of chemotherapy aiming for disease control and potential resection. Serial CT examinations, endoscopy, and biopsy were performed after the fourth, sixth, and eighth cycle of treatment. The primary tumor and lymph nodes seen on CT were compared with operative findings. RESULTS: After completion of chemotherapy, CT findings were correct in 23 patients. Fourteen of them had operable tumors and nine were inoperable. However, the CT findings were either equivocal or incorrect in the remaining seven patients. CONCLUSION: Chemotherapy is now able to downstage a previously inoperable gastric cancer, and CT is an accurate method in identifying those patients who can proceed to resection.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: Adenocarcinoma/*drug therapy/radiography/secondary/surgery,Adult,Aged,Aged, 80 and over,Antibiotics, Antineoplastic/administration & dosage,Antimetabolites, Antineoplastic/administration & dosage,Antineoplastic Agents/administration & dosage,Antineoplastic Combined Chemotherapy Protocols/*therapeutic use,Biopsy,Cisplatin/administration & dosage,Doxorubicin/administration & dosage,Epirubicin/administration & dosage,Female,Fluorouracil/administration & dosage,*Gastrectomy,Gastroscopy,Humans,Laparotomy,Liver Neoplasms/secondary,Lymphatic Metastasis,Methotrexate/administration & dosage,Middle Aged,Neoplasm Invasiveness,Neoplasm Staging,Retrospective Studies,Stomach Neoplasms/*drug therapy/radiography/surgery,*Tomography, X-Ray Computed
URI: http://olympias.lib.uoi.gr/jspui/handle/123456789/22686
ISSN: 0942-8925
Link: http://www.ncbi.nlm.nih.gov/pubmed/8661575
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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