Cyclosporin a therapy in patients with primary Sjogren's syndrome: results at one year (Journal article)

Drosos, A. A./ Skopouli, F. N./ Galanopoulou, V. K./ Kitridou, R. C./ Moutsopoulos, H. M.


We present our experience with small doses of cyclosporine A (CyA), 5 mg/kg/day, in patients with primary Sjogren's syndrome treated for up to 12 months. Subjective improvement in xerostomia occurred at 6 months of treatment, without objective improvement in any sicca parameters. At 12 months, xerostomia improved slightly, but minor salivary gland histology worsened. We conclude that small doses of CyA in patients with primary Sjogren's syndrome for up to 12 months are rather ineffective.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: Clinical Trials as Topic,Cyclosporins/adverse effects/*therapeutic use,Double-Blind Method,Humans,Sjogren's Syndrome/*drug therapy
URI: http://olympias.lib.uoi.gr/jspui/handle/123456789/22651
ISSN: 0301-3847
Link: http://www.ncbi.nlm.nih.gov/pubmed/3296152
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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