Demonstration and identification of monoclonal proteins in the urine of patients with Sjogren's syndrome (Journal article)

Moutsopoulos, H. M./ Costello, R./ Drosos, A. A./ Mavridis, A. K./ Papadopoulos, N. M.

Fresh sera and concentrated urine from 17 patients with primary Sjogren's syndrome (SS) were fractionated by high-resolution agarose electrophoresis to investigate the presence of monoclonal immunoglobulins or their components. Homogeneous protein bands were found in the gamma-globulin region in 47% of serum samples and 76% of urine specimens of all patients tested. These monoclonal proteins were detected more often in patients with extraglandular SS (77% in serum, 100% in the urine) than in patients with glandular SS (14% in serum, 43% in the urine). Immunofixation electrophoresis showed that the majority of these monoclonal proteins were free kappa or lambda light chains. Fractionation of unconcentrated parotid salivas from five SS patients failed to reveal the presence of monoclonal light chains or immunoglobulins. The present findings further substantiate our previous observation that a monoclonal process coexists with the polyclonal activation in SS patients.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: Adult,Aged,Electrophoresis,Female,Humans,Immunoglobulin Light Chains/analysis/urine,Immunoglobulin kappa-Chains/analysis/urine,Immunoglobulin lambda-Chains/analysis/urine,Immunoglobulins/*urine,Male,Middle Aged,Sjogren's Syndrome/blood/*urine
ISSN: 0003-4967
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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