Diagnostic accuracy, internal consistency, and convergent validity of the Greek version of the patient health questionnaire 9 in diagnosing depression in rheumatologic disorders (Journal article)

Hyphantis, T./ Kotsis, K./ Voulgari, P. V./ Tsifetaki, N./ Creed, F./ Drosos, A. A.


OBJECTIVE: The Patient Health Questionnaire 9 (PHQ-9) was developed to screen for depressive disorders in community, primary care, and medical settings. We aimed to estimate its diagnostic accuracy, internal consistency, reliability, and convergent validity in diagnosing major depressive disorder (MDD) in Greek patients with rheumatologic disorders. METHODS: In a 2-phase sampling design study, we recruited 475 patients with established rheumatologic disorders. One of 2 of the high scorers (PHQ-9 score >/=9, n = 85) and 1 of 3 of the low scorers (PHQ-9 score 0-8, n = 128) were interviewed using the Mini International Neuropsychiatric Interview to confirm MDD. A receiver operator characteristic curve analysis was performed to confirm the optimum threshold value. The scale's dimensional structure was tested with factor analysis, and internal consistency reliability was assessed with Cronbach's alpha. Psychological distress (Symptom Check List-90-Revised [SCL-90-R]), disability (Health Assessment Questionnaire disability index), and health-related quality of life (HRQOL; World Health Organization Quality of Life Instrument [WHOQOL-BREF]) were also assessed to test convergent validity with bivariate correlations. RESULTS: At an optimum threshold of 10, the PHQ-9 showed a sensitivity of 81.2% and a specificity of 86.8%. The area under the curve was 0.91. The PHQ-9 presented unidimensional structure with good scale reliability (alpha = 0.82). The PHQ-9 score presented the greatest correlations with SCL-90-R depression (r = 0.736) and WHOQOL-BREF mental HRQOL scales (r = -0.571), and all other correlations with disability and HRQOL were in the expected direction. CONCLUSION: At a cutoff of 10, the PHQ-9 is an accurate, reliable, and valid measure for screening for MDD among Greek rheumatologic patients.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: Adult,Aged,Checklist,Chi-Square Distribution,Cultural Characteristics,Depressive Disorder, Major/ diagnosis/etiology,Disability Evaluation,Female,Greece,Humans,Language,Male,Middle Aged,Predictive Value of Tests,Psychiatric Status Rating Scales,Quality of Life,Questionnaires,Reproducibility of Results,Rheumatic Diseases/ psychology,Sensitivity and Specificity,Severity of Illness Index
URI: http://olympias.lib.uoi.gr/jspui/handle/123456789/22515
ISSN: 2151-4658
Link: http://onlinelibrary.wiley.com/store/10.1002/acr.20505/asset/20505_ftp.pdf?v=1&t=hh8xxbfg&s=99fede6a50a363d3e2cbf4fe0b444fe8a9c10c18
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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