Differential expression of dysadherin in papillary thyroid carcinoma and microcarcinoma: correlation with E-cadherin (Journal article)
Batistatou, A./ Charalabopoulos, K./ Nakanishi, Y./ Vagianos, C./ Hirohashi, S./ Agnantis, N. J./ Scopa, C. D.
Dysadherin is a novel glycoprotein, with an anti-cell-cell adhesion function. The aim of the present study was to examine the expression of dysadherin in thyroid papillary microcarcinoma (PMC), to associate it with the expression of E-cadherin and to investigate whether there are differences with papillary carcinoma (PC). A statistically significant difference in dysadherin and E-cadherin expression between PC and PMC and a negative correlation between E-cadherin and dysadherin expression regardless of tumor size were noted. Based on these findings it is hypothesized that retained cell-cell adhesion, through maintenance of the E-cadherin adhesion system, in PMC prevents neoplastic cells from dissociating easily from each other and metastasizing. Increased dysadherin expression is possibly one of the post-transcriptional mechanisms responsible for E-cadherin downregulation in thyroid papillary neoplasia.
|Institution and School/Department of submitter:||Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής|
|Keywords:||Cadherins/*metabolism,Carcinoma, Papillary, Follicular/*metabolism/*pathology,Gene Expression,Humans,Immunohistochemistry,Membrane Glycoproteins/*biosynthesis,Neoplasm Proteins/*biosynthesis,Thyroid Neoplasms/*metabolism/*pathology|
|Appears in Collections:||Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)|
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