Distensibility and pulse wave velocity of the thoracic aorta in patients with juvenile idiopathic arthritis: An MRI study (Journal article)
Argyropoulou, M. I./ Kiortsis, D. N./ Daskas, N./ Xydis, V./ Mavridis, A./ Efremidis, S. C./ Siamopoulou, A.
Objective. An increased incidence of cardiovascular disease has been found in rheumatic disorders. Changes in the variables of aortic elasticity in patients with juvenile idiopathic arthritis (JIA) were evaluated and their relationship to inflammation, anti-rheumatic drugs and traditional cardiovascular risk factor's were investigated in this study Methods. Phase contrast MR was performed in 31 patients with JIA and 28 age and sex matched controls to evaluate the aortic distensibility, and pulse wave velocity (PWV). Disease activity, variables, plasma lipid profile, homocysteine, thyroid hormones, glucose and insulin were assessed in the patients. Results. Eighteen patients had oligoarticular 6 polyarticular and 7 systemic disease. Distensibility, was lower (mean: 10.25; SD: 4.18) and PWV was higher (mean: 3.68; SD: 1.59) in the patients compared to the controls (mean: 13.4; SD: 4,99), (mean: 1.38; SD: 0.54) respectively (p < 0.01). A positive correlation between PWV and age was observed ill the patients (r(s) = 0.47, p < 0.01) and controls (r(s) = 0.72, p < 0.01), and a negative correlation between distensibility, and age in the patients (r(s) = -0.59, p < 0.01) and controls (r(s) = -0.63, p < 0.01). No statistically significant correlations were found between distensibility and PWV and metabolic and disease activity parameters. When distensibility and PWV were adjusted for age no significant differences were found between the three subtypes of JIA. Conclusion. JIA is associated with increased aortic stiffness that might suggest subclinical atherosclerosis. Early detection and follow-up by noninvasive methods may be useful in the prevention of future cardiovascular disease.
|Institution and School/Department of submitter:||Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής|
|Keywords:||juvenile idiopathic arthritis,aorta,atherosclerosis,mri,pulse wave velocity,distensibility,coronary-artery disease,c-reactive protein,rheumatoid-arthritis,cardiovascular-disease,marfan-syndrome,heart-disease,risk-factors,atherosclerosis,age,hypercholesterolemia|
|Link:||<Go to ISI>://000187282800020|
|Appears in Collections:||Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)|
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