D-penicillamine toxicity in Greek patients with rheumatoid arthritis: anti-Ro(SSA) antibodies and cryoglobulinemia are predictive factors (Journal article)

Vlachoyiannopoulos, P. G./ Zerva, L. V./ Skopouli, F. N./ Drosos, A. A./ Moutsopoulos, H. M.


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dc.contributor.authorVlachoyiannopoulos, P. G.en
dc.contributor.authorZerva, L. V.en
dc.contributor.authorSkopouli, F. N.en
dc.contributor.authorDrosos, A. A.en
dc.contributor.authorMoutsopoulos, H. M.en
dc.date.accessioned2015-11-24T19:23:35Z-
dc.date.available2015-11-24T19:23:35Z-
dc.identifier.issn0315-162X-
dc.identifier.urihttp://olympias.lib.uoi.gr/jspui/handle/123456789/22336-
dc.rightsDefault Licence-
dc.subjectAntibodies, Antinuclear/*analysisen
dc.subjectArthritis, Rheumatoid/complications/*drug therapy/ethnology/immunologyen
dc.subjectCryoglobulinemia/*complicationsen
dc.subjectDrug Eruptionsen
dc.subjectFemaleen
dc.subjectFluorescent Antibody Techniqueen
dc.subjectForecastingen
dc.subjectGreece/ethnologyen
dc.subjectHumansen
dc.subjectMaleen
dc.subjectPenicillamine/*adverse effectsen
dc.titleD-penicillamine toxicity in Greek patients with rheumatoid arthritis: anti-Ro(SSA) antibodies and cryoglobulinemia are predictive factorsen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/1827158-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate1991-
heal.abstractSixty-two consecutive patients, with rheumatoid arthritis (RA) who received D-penicillamine were studied retrospectively to identify predictive risk factors for D-penicillamine toxicity. Thirty-two developed side effects, while 30 did not. The clinical picture in both groups was similar, but the group with D-penicillamine toxicity was characterized by a high incidence of anti-Ro(SSA) antibodies (p less than 0.01) or circulating cryoglobulins (p less than 0.001). The presence of anti-Ro(SSA) antibodies was not correlated with the presence of circulating cryoglobulins (p greater than 0.5), while the coefficient of contingency (C) between anti-Ro(SSA) and cryoglobulins was 0.131. Men were predisposed to express more renal pathology (p less than 0.025), while anti-Ro(SSA) positive patients with RA more often expressed rashes (p less than 0.0001) and acute febrile reactions (p less than 0.05) than anti-Ro(SSA) negative patients. These observations should be considered when making therapeutic decisions at least for Greek patients with RA.en
heal.journalNameJ Rheumatolen
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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