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  5. Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ
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Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/22289
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dc.contributor.authorToumpoulis, I. K.en
dc.contributor.authorAnagnostopoulos, C. E.en
dc.contributor.authorDrossos, G. E.en
dc.contributor.authorMalamou-Mitsi, V. D.en
dc.contributor.authorPappa, L. S.en
dc.contributor.authorKatritsis, D. G.en
dc.date.accessioned2015-11-24T19:23:21Z-
dc.date.available2015-11-24T19:23:21Z-
dc.identifier.issn0022-5223-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/22289-
dc.rightsDefault Licence-
dc.subjectAnimalsen
dc.subjectAorta, Thoracic/pathology/*surgeryen
dc.subjectAortic Diseases/*complicationsen
dc.subjectArterial Occlusive Diseases/*complicationsen
dc.subjectBlood Pressure/physiologyen
dc.subjectDisease Models, Animalen
dc.subject*Ischemic Preconditioningen
dc.subjectSpinal Cord/*blood supplyen
dc.subjectSpinal Cord Injuries/etiology/pathology/*prevention & controlen
dc.subjectSwineen
dc.titleEarly ischemic preconditioning without hypotension prevents spinal cord injury caused by descending thoracic aortic occlusionen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.primary10.1067/mtc.2003.174-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/12771875-
heal.identifier.secondaryhttp://ac.els-cdn.com/S0022522303501076/1-s2.0-S0022522303501076-main.pdf?_tid=6c589504451bd75a9184ceb76183ad53&acdnat=1333099529_456343a606143d6fe04a2dd022435676-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate2003-
heal.abstractOBJECTIVE: Postoperative neurologic deficits after thoracic aortic reconstruction vary widely. Our previous study showed that delayed ischemic preconditioning could prevent spinal cord injury caused by occlusion of the descending thoracic aorta in pigs. We investigated early ischemic preconditioning in the same model. METHODS: Twenty-eight pigs were divided into 4 groups: group 1 (n = 6) underwent a sham operation, group 2 (n = 6) underwent aortic occlusion for 20 minutes, group 3 (n = 8) underwent aortic occlusion for 35 minutes, and group 4 (n = 8) underwent aortic occlusion for 20 minutes and underwent aortic occlusion 80 minutes later without hypotension for 35 minutes. Aortic occlusion was accomplished by using 2 balloon occlusion catheters placed fluoroscopically at T6 to T8 above the diaphragm and at the aortic bifurcation. Neurologic evaluation was performed by an independent observer according to the Tarlov scale (0-4). The lower thoracic and lumbar spinal cords were harvested at 120 hours and examined histologically with hematoxylin-and-eosin stain. Histologic results (number of neurons and grade of inflammation) were scored (0-4) and were similarly analyzed. Statistical analysis was by means of the Kruskal-Wallis test. RESULTS: Group 4 had a better neurologic outcome at 24, 48, and 120 hours in comparison with group 3 (P <.001). The histologic changes were proportional to the neurologic test scores, with the more severe and extensive gray matter damage in animals of group 3 (number of neurons, P <.001; grade of inflammation, P <.001). CONCLUSION: Early ischemic preconditioning without hypotension protects against spinal cord injury after aortic occlusion, as confirmed by using the Tarlov score and histopathology.en
heal.journalNameJ Thorac Cardiovasc Surgen
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
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