Early, intracoronary growth hormone administration attenuates ventricular remodeling in a porcine model of myocardial infarction (Journal article)

Mitsi, A. C./ Hatzistergos, K. E./ Niokou, D./ Pappa, L./ Baltogiannis, G. G./ Tsalikakis, D. G./ Papalois, A./ Kyriakides, Z. S./ Malamou-Mitsi, V./ Kolettis, T. M.

OBJECTIVE: Ventricular remodeling is a common corollary of myocardial infarction. We hypothesized that this process may be attenuated by growth hormone, administered as a single high-dose, selectively in the infarct zone, early postmyocardial infarction. DESIGN: In 35 pigs (29+/-4 kg), myocardial infarction was generated by inflation of an over-the-wire angioplasty balloon in the circumflex artery for 60 min and 5 further pigs were sham-operated. Ten minutes after reperfusion, the pigs were randomized (2:1) to either growth hormone (1 IU/kg) (n=23) or normal saline (n=12), delivered via the balloon catheter. All survivors were treated with captopril and were sacrificed 4 weeks after myocardial infarction. RESULTS: Compared to controls, growth hormone-treated animals displayed lower heart weight (4.1+/-0.5 g/kg body weight, versus 3.4+/-0.4 g/kg, respectively, p=0.003) and dimensions (left ventricular short axis diameter 46+/-7 mm versus 37+/-6 mm, p=0.01; right ventricular short axis diameter 38+/-7 mm versus 30+/-5 mm p=0.001). Growth hormone increased wall thickness in the infarct (6.0+/-1.8 in controls versus 9.9+/-3.7 in treated animals, p=0.004) and non-infarct zones (10.6+/-1.8 in controls versus 15.5+/-3.8 in treated animals, p=0.0006) and produced higher (p<0.05) microvascular density in both zones. CONCLUSION: Intracoronary administration of growth hormone attenuates left and right ventricular remodeling by inducing hypertrophy and by enhancing angiogenesis.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: Animals,Antihypertensive Agents/administration & dosage,Captopril/administration & dosage,Disease Models, Animal,Growth Hormone/*administration & dosage/*metabolism,Humans,Myocardial Infarction/*metabolism/pathology,Neovascularization, Pathologic/*chemically induced/metabolism/pathology,Swine,Ventricular Remodeling/*drug effects
URI: https://olympias.lib.uoi.gr/jspui/handle/123456789/22277
ISSN: 1096-6374
Link: http://www.ncbi.nlm.nih.gov/pubmed/16624608
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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