Effect of L-carnitine supplementation on lipid parameters in hemodialysis patients (Journal article)

Elisaf, M. S./ Bairaktari, E./ Katopodis, K./ Pappas, M./ Sferopoulos, G./ Tzallas, C./ Tsolas, O./ Siamopoulos, K. C.

It has been reported that cumulative carnitine losses through dialysis membranes may worsen hyperlipidemia during long-term hemodialysis. However, carnitine supplementation has not shown a consistent beneficial response. We undertook the present study to determine if there is any hypolipidemic effect of L-carnitine on Greek dialysis patients in concert with the dialysate buffer composition (acetate or bicarbonate). A total of 28 patients (16 male, 12 female), mean age 43 years (range 21-61), with end-stage renal disease on maintenance hemodialysis for a mean period of 25 months (range 7-84) were studied. The dialysis schedule was 4 h, 3 times/week using cuprophane hollow-fiber dialyzers and acetate (n = 14) or bicarbonate (n = 14) dialysate. In all patients L-carnitine (5 mg/kg body weight) was infused intravenously 3 times/week at the end of each hemodialysis session. Blood samples for carnitine and lipid determinations were obtained before treatment, and 3 and 6 months following treatment. Even though L-carnitine did not modify most of the serum lipid levels, a significant decrease in serum triglycerides was evident in the whole group of patients (from 225 +/- 76 to 201 +/- 75 mg/dl, p = 0.03). Furthermore, L-carnitine could decrease serum triglycerides only in hypertriglyceridemic patients (from 260 +/- 64 to 226 +/- 82 mg/dl, p < 0.05). L-Carnitine resulted in a reduction of serum triglycerides in both patients on bicarbonate and on acetate dialysis, while there were no significant differences in the changes of lipid parameters after L-carnitine between the two groups of hemodialysis patients. We conclude that relatively low doses of L-carnitine supplementation could contribute to the management of some hypertriglyceridemic hemodialysis patients.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: Adult,Apolipoproteins/blood,Buffers,Carnitine/*administration & dosage/blood,Cholesterol/blood,Female,Hemodialysis Solutions,Humans,Hypertriglyceridemia/drug therapy/etiology,Kidney Failure, Chronic/blood/complications/therapy,Lipids/*blood,Lipoproteins/blood,Male,Middle Aged,*Renal Dialysis,Triglycerides/blood
URI: https://olympias.lib.uoi.gr/jspui/handle/123456789/22195
ISSN: 0250-8095
Link: http://www.ncbi.nlm.nih.gov/pubmed/9730566
http://content.karger.com/ProdukteDB/produkte.asp?doi=10.1159/000013386
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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