Effects of actinomycin D on the lysosomes of newborn rat hepatocytes (Journal article)

Kotoulas, O. B.

The effects of actinomycin D on newborn rat liver were studied by using biochemical assays, electron microscopy, and quantitative morphometry. Actinomycin prevented the normal postnatal rise in acid a 1,4 glucosidase (maltase) activity and the breakdown of lysosomal glycogen. The results suggest that the postnasal increase in acid glucosidase activity is protein synthesis dependent. This enzyme is critical for the catabolism of the lysosomal glycogen in newborn rat hepatocytes.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: Animals,Animals, Newborn,Dactinomycin/*pharmacology,Liver/enzymology,Liver Glycogen/*metabolism,Lysosomes/*drug effects/ultrastructure,Rats,Rats, Inbred Strains,alpha-Glucosidases/*antagonists & inhibitors/metabolism
URI: http://olympias.lib.uoi.gr/jspui/handle/123456789/22129
ISSN: 0003-276X
Link: http://www.ncbi.nlm.nih.gov/pubmed/3279867
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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