Effects of actinomycin D on the lysosomes of newborn rat hepatocytes (Journal article)

Kotoulas, O. B.


The effects of actinomycin D on newborn rat liver were studied by using biochemical assays, electron microscopy, and quantitative morphometry. Actinomycin prevented the normal postnatal rise in acid a 1,4 glucosidase (maltase) activity and the breakdown of lysosomal glycogen. The results suggest that the postnasal increase in acid glucosidase activity is protein synthesis dependent. This enzyme is critical for the catabolism of the lysosomal glycogen in newborn rat hepatocytes.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: Animals,Animals, Newborn,Dactinomycin/*pharmacology,Liver/enzymology,Liver Glycogen/*metabolism,Lysosomes/*drug effects/ultrastructure,Rats,Rats, Inbred Strains,alpha-Glucosidases/*antagonists & inhibitors/metabolism
URI: http://olympias.lib.uoi.gr/jspui/handle/123456789/22129
ISSN: 0003-276X
Link: http://www.ncbi.nlm.nih.gov/pubmed/3279867
http://onlinelibrary.wiley.com/store/10.1002/ar.1092200112/asset/1092200112_ftp.pdf?v=1&t=h1ymggv5&s=0e855a2e7a77b1f620509b7c909626c5acc20f85
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

Files in This Item:
File Description SizeFormat 
Kotoulas-1988-Effects of actinomyc.pdf725.06 kBAdobe PDFView/Open    Request a copy



 Please use this identifier to cite or link to this item:
http://olympias.lib.uoi.gr/jspui/handle/123456789/22129
  This item is a favorite for 0 people.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.