Effects of phosphodiesterase-5 inhibitors on Leydig cell secretory function in oligoasthenospermic infertile men: a randomized trial (Journal article)

Dimitriadis, F./ Tsambalas, S./ Tsounapi, P./ Kawamura, H./ Vlachopoulou, E./ Haliasos, N./ Gratsias, S./ Watanabe, T./ Saito, M./ Miyagawa, I./ Sofikitis, N.

OBJECTIVE: to evaluate the effects of phosphodiesterase-5 inhibitors (PDE5-i) on Leydig cell secretory function (LCSF). PATIENTS AND METHODS: in all, 75 men with oligoasthenospermia were treated daily for 12 weeks with either vardenafil (23 men, group A), sildenafil (25 men, group B) or l-carnitine (26 men, group C); a further group of 22 men with oligoasthenospermia (group D) received no treatment. Serum levels of insulin-like-3 peptide (INSL3) were evaluated before and after the end of the treatment in each of groups A, B and C, respectively. Serum INSL3 levels were measured in each participant of group D before and after the 12-week experimental period. RESULTS: within group A and B, the peripheral serum mean INSL3 concentration, sperm concentration, percentage of motile spermatozoa, and percentage of morphologically normal spermatozoa were significantly greater after PDE5-i treatment than before. CONCLUSION: we suggest that PDE5-i enhances LCSF, as the mean INSL3 concentration was significantly greater after PDE5-i administration than before, within groups A and B. This enhancement in LCSF might contribute to the increase in sperm concentration and sperm motility after administration of PDE5-i.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: Analysis of Variance,Carnitine,Humans,Imidazoles,Insulin/blood/*secretion,Leydig Cells/*drug effects/secretion,Male,Oligospermia/blood/*drug therapy,Phosphodiesterase 5 Inhibitors/*therapeutic use,Piperazines,Proteins/*secretion,Purines,Sperm Count,Sperm Motility,Sulfones,Treatment Outcome,Triazines
URI: http://olympias.lib.uoi.gr/jspui/handle/123456789/22069
ISSN: 1464-410X
Link: http://www.ncbi.nlm.nih.gov/pubmed/20184572
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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