Effects of sulfhydryl compounds on cancer cell lines: I: N-(2-mercaptopropionyl)-glycine exerts antiproliferating effects and antagonizes the stimulating effect of prolactin on MCF-7 human breast cancer cells (Journal article)

Malamas, F. M./ Thomas, C. G./ Stefos, T./ Evangelou, A.

The effects of prolactin (PRL) and N-(2-mercaptopropionyl)-glycine (MPG) on the growth of MCF-7 human breast cancer cells, and the influence of MPG on PRL-induced MCF- 7 cell proliferation, when added simultaneously to the culture medium, were examined. Prolactin at concentrations of 200 ng/ml - 350 ng/ml enhanced the growth of MCF-7 cells, while at lower and higher concentrations its action was diminished. MPG alone at concentrations above 2 mM caused a decrease in cell proliferation. When PRL and MPG were added simultaneously to the culture medium, an inhibitory effect on PRL-induced MCF-7 cell proliferation was observed, at concentrations of MPG lower than 2 mM.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: Breast Neoplasms,Cell Division/*drug effects,Cell Line, Tumor,Female,Humans,Prolactin/*pharmacology,Sulfhydryl Compounds/*pharmacology,Tiopronin/*pharmacology
URI: https://olympias.lib.uoi.gr/jspui/handle/123456789/22047
ISSN: 0258-851X
Link: http://www.ncbi.nlm.nih.gov/pubmed/17436584
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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