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  4. Τμήμα Ιατρικής
  5. Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ
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Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/22008
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dc.contributor.authorKalamidas, S. A.en
dc.contributor.authorKondomerkos, D. J.en
dc.contributor.authorKotoulas, O. B.en
dc.contributor.authorHann, A. C.en
dc.date.accessioned2015-11-24T19:20:03Z-
dc.date.available2015-11-24T19:20:03Z-
dc.identifier.issn1059-910X-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/22008-
dc.rightsDefault Licence-
dc.subjectAnimalsen
dc.subjectAnimals, Newbornen
dc.subjectAutophagy/*drug effectsen
dc.subjectImmunosuppressive Agents/*pharmacologyen
dc.subjectLiver/*drug effects/metabolism/ultrastructureen
dc.subjectLiver Glycogen/*metabolismen
dc.subjectMicroscopy, Electronen
dc.subjectRatsen
dc.subjectSirolimus/*pharmacologyen
dc.titleElectron microscopic and biochemical study of the effects of rapamycin on glycogen autophagy in the newborn rat liveren
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.primary10.1002/jemt.20032-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/14988919-
heal.identifier.secondaryhttp://onlinelibrary.wiley.com/store/10.1002/jemt.20032/asset/20032_ftp.pdf?v=1&t=h1ym1093&s=cb91cbe5aca4fdc82432ccfd7ef36ef47297a134-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate2004-
heal.abstractThe effects of rapamycin on glycogen autophagy in the newborn rat liver were studied using biochemical determinations, electron microscopy, and morphometric analysis. Rapamycin increased the fractional volume of hepatocytic autophagic vacuoles, the liver lysosomal glycogen-hydrolyzing activity of acid glucosidase, the degradation of glycogen inside the autophagic vacuoles, and decreased the activity of acid mannose 6-phosphatase. These findings suggest that rapamycin, a known inhibitor of the mammalian target of rapamycin (mTOR) signaling, induces glycogen autophagy in the newborn rat hepatocytes. mTOR may participate in the regulation of this process.en
heal.journalNameMicrosc Res Techen
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
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