Enhancement of human T lymphocyte function by prothymosin alpha: increased production of interleukin-2 and expression of interleukin-2 receptors in normal human peripheral blood T lymphocytes (Journal article)

Baxevanis, C. N./ Frillingos, S./ Seferiadis, K./ Reclos, G. J./ Arsenis, P./ Katsiyiannis, A./ Anastasopoulos, E./ Tsolas, O./ Papamichail, M.

The in vitro incubation of phytohemagglutinin (PHA)- or alloantigen-stimulated peripheral blood T cells with prothymosin alpha (ProT alpha) resulted in a marked and reproducible increase in the production of interleukin-2 (IL-2). Incubation of T cells with ProT alpha, in the absence of PHA or alloantigen, failed to induce any production of IL-2. ProT alpha by itself did not exert any IL-2 activity. Finally, ProT alpha was shown to increase the expression of IL-2 receptors on phytohemagglutinin- or alloantigen-activated T cells. These data provide the basis for understanding the in vitro immunoenhancing effects of ProT alpha in cellular immune systems.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: Adult,Humans,Interleukin-2/biosynthesis,Isoantigens/administration & dosage,Phytohemagglutinins/pharmacology,Protein Precursors/*pharmacology,Receptors, Interleukin-2/biosynthesis/drug effects,T-Lymphocytes/*drug effects/immunology,Thymosin/*analogs & derivatives/pharmacology
URI: https://olympias.lib.uoi.gr/jspui/handle/123456789/21940
ISSN: 0892-3973
Link: http://www.ncbi.nlm.nih.gov/pubmed/2092041
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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