Epidural analgesia attenuates the systemic stress response to upper abdominal surgery: a randomized trial (Journal article)

Kouraklis, G./ Glinavou, A./ Raftopoulos, I./ Alevisou, V./ Lagos, G./ Karatzas, G.

The effects of combined general anaesthesia and epidural analgesia in various endocrine and metabolic parameters were studied before, during, at the end, and 72 h after upper abdominal surgery, in an effort to further elucidate the role of epidural analgesia in the endocrine and metabolic response. 50 patients were randomly assigned into groups A and B, which received general anaesthesia alone and combined general anaesthesia and epidural analgesia, respectively. The effects of surgical stress in the plasma concentration of ACTH (P <0.001), cortisol (P <0.01), aldosterone (P <0.05), FFA (P <0.05) and glucose (P <0.01) were significantly less pronounced in the group of patients who received combined general anaesthesia and epidural analgesia. However, there were no significant differences between the two groups in regard with plasma TSH, T3, T4, glucagon or Na+ concentration. These results indicate that the combination of general anaesthesia and epidural analgesia attenuate, but does not inhibit, the endocrine and metabolic response to upper abdominal surgery.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: epidural analgesia,metabolic response,endocrine response,stress,anaesthesia,metabolic response,endocrine response,bupivacaine,morphine,blockade,cholecystectomy,pain
URI: https://olympias.lib.uoi.gr/jspui/handle/123456789/21903
ISSN: 0020-8868
Link: <Go to ISI>://000171003700018
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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