Evaluation of the end-expiratory pressure by multiple linear regression and Fourier analysis in humans (Journal article)

Mygdalou, A./ Psarakis, C./ Vassiliou, P./ Dalavanga, Y. A./ Mandragos, C./ Constantopoulos, S. H./ Behrakis, P. K./ Vassiliou, M. P.

This study was designed to compare the end-expiratory pressure (EEP) during mechanical ventilation (MV) measured dynamically (EEPdyn), by multiple linear regression (MLR) of the airway pressure (Pao) vs volume (V) and flow (V') and after Fourier analysis (FA) of the Pao and V'. Pao and V' were recorded from 32 ICU patients (II without respiratory disease, 10 COPD, II ARDS) under MV, at three levels of PEEPe (0, 5 and 10 hPa). Volume was calculated by numerical integration of V'. Data were analysed by MLR and FA, while the actual value of EEPdyn was recognised on the Pao signal at zero V' and V. EEPdyn, EEPMLR and EEPFA were compared for all patients, for each group of patients and for every level of applied PEEPe. Despite the different evaluation of respiratory mechanics between MLR and FA, the EEP values were always not significantly different between the three applied methods (P > 0.05). A high degree of correlation was found between them, taken two at a time (r > 0.99, P < 0.001). Two non-invasive analytical methods for the evaluation of respiratory mechanics during MV, MLR and FA offer a reliable and clinically useful estimation of EEP during MV.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: Adult,Aged,Aged, 80 and over,Analysis of Variance,Brain Injuries/physiopathology/therapy,Female,*Fourier Analysis,Humans,Intensive Care,*Linear Models,Male,Middle Aged,*Positive-Pressure Respiration,Pulmonary Disease, Chronic Obstructive/physiopathology/therapy,Respiration, Artificial,Respiratory Distress Syndrome, Adult/physiopathology/therapy,Respiratory Mechanics
URI: http://olympias.lib.uoi.gr/jspui/handle/123456789/21796
ISSN: 0954-6111
Link: http://www.ncbi.nlm.nih.gov/pubmed/12194633
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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