Expression of cell adhesion molecule CD44 in human gastric cancer. A correlation with P53 and Rb proteins, the HLA-DR antigen and the proliferative activity (Journal article)

Goussia, A. C./ Ioachim, E. E./ Agnantis, N. J./ Zagorianakou, P./ Vougiouklakis, T./ Tsianos, E. V./ Kappas, A.

The expression of the CD44 standard (CD44s) was examined immunohistochemically in a series of 61 gastric adenocarcinomas and analyzed the relation with the expression of HLA-DR antigen, the p53 and Rb protein expression, the proliferation indices Ki-67 and PCNA as well as with conventional clinicopathological variables. CD44s immunoreactivity was detected in 47.6% of the cases. The incidence of CD44s expression did not differ among histological types of carcinomas. CD44s expression was significantly related to depth of invasion (p=0.03) and to Ki-67 positive rate (p=0.018). A trend for correlation with vessel invasion was also observed (p=0.06). The relation of CD44 expression with the other studied variables was insignificant. These data suggest that CD44s may have a major role as adhesion molecule in the progression of gastric carcinomas. In addition, the expression of CD44s is associated with proliferation, suggesting that in gastric cancer CD44s may have a role in tumor cell growth.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: diffuse-type,differential expression,extracellular-matrix,variant,isoforms,intestinal-type,adenocarcinomas,progression,metastasis,integrins,carcinoma
ISSN: 0886-3849
Link: <Go to ISI>://WOS:000087559500006
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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