Expression of the alpha/beta and gamma/delta T-cell receptors in 57 cases of peripheral T-cell lymphomas. Identification of a subset of gamma/delta T-cell lymphomas (Journal article)

Gaulard, P./ Bourquelot, P./ Kanavaros, P./ Haioun, C./ Le Couedic, J. P./ Divine, M./ Goossens, M./ Zafrani, E. S./ Farcet, J. P./ Reyes, F.

Fifty-seven cases of peripheral T-cell lymphoma were studied for cell expression of the T-cell receptor (TCR) chains, using monoclonal antibodies specific for the beta chain (beta F1) of the alpha/beta TCR, and for the delta chain (anti-TCR delta-1) of the gamma/delta TCR. Three different patterns were demonstrated: in 39 cases (69%), the phenotype (CD3+beta F1+TCR delta-1-) was that of most normal T cells. A second pattern was found on six cases (10%), which were of CD3+beta F1-TCR delta-1+ phenotype, and in which DNA analysis showed a clonal rearrangement of the delta locus in the five cases studied. It is suggested that these cases are the neoplastic counterpart of the small subpopulation of normal T cells that express gamma delta receptor. It is of considerable interest that these gamma delta lymphomas had unusual clinicopathologic presentations, as one case corresponded to a lethal midline granuloma and the five others to hepatosplenic lymphomas with a sinusal/sinusoidal infiltration in spleen, marrow, and liver. The fact that the distribution of the neoplastic gamma delta cells in the splenic red pulp resembles that of normal gamma delta cells reinforces the concept of a preferential homing of gamma delta T cells to this tissue. A third pattern (CD3 +/- beta F1-TCR delta-1-) was seen in 12 cases (21%), in which, by contrast to normal post-thymic T cells, no evidence of either alpha beta or gamma delta T cell receptor was found.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: Antibodies, Monoclonal/diagnostic use,Antigens, CD3,Antigens, Differentiation, T-Lymphocyte/analysis,Gene Expression,Gene Rearrangement, alpha-Chain T-Cell Antigen Receptor,Gene Rearrangement, beta-Chain T-Cell Antigen Receptor,Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor,Humans,Immunohistochemistry,Lymphoma/diagnosis/*immunology,Phenotype,Receptors, Antigen, T-Cell/analysis/genetics/*immunology,Staining and Labeling,T-Lymphocytes/immunology
ISSN: 0002-9440
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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