External beam irradiation in angioplasted arteries of hypercholesterolemic rabbits. The dose and time effect (Journal article)

Kalef-Ezra, J./ Michalis, L. K./ Malamou-Mitsi, V./ Tsekeris, P./ Katsouras, C./ Boziari, A./ Toumpoulis, I./ Bozios, G./ Charchanti, A./ Sideris, D. A.


PURPOSE: To study the dose and time effect of external beam irradiation on the morphometry of both angioplasted and nonangioplasted arteries in a hypercholesterolemic rabbit model. METHODS AND MATERIALS: Eight groups of rabbit femoral arteries were studied: arteries (a) with no intervention, (b) irradiated with a 12-Gy 6 MV X-ray dose, (c) with a 18-Gy, (d) treated with balloon angioplasty, (e) dosed with 12-Gy half an hour post-angioplasty, (f) dosed with 18-Gy half an hour post-angioplasty, (g) dosed with 12-Gy 48 h post angioplasty, (g) dosed with 18-Gy 48 h post angioplasty. RESULTS: External irradiation at either 12 or 18 Gy was not found to change vessel morphometry in noninjured arteries. The 12-Gy dose given soon after angioplasty further increased percentage stenosis (63% on the average), despite the preservation of the lumen cross-sectional area. Positive remodeling was not observed in arteries given 18-Gy half an hour post angioplasty to counterbalance the increased neointimal formation. Therefore, this treatment resulted in a drastic reduction in lumen area and in enhancement of percentage stenosis (84% on the average). On the contrary, the delayed irradiation of the angioplasted arteries at either 12 or 18 Gy was not found to influence any of the studied morphometric parameters 5 weeks after angioplasty. CONCLUSIONS: Uniform external beam irradiation up to 18 Gy was well tolerated by intact femoral arteries. Prompt 12- or 18-Gy irradiations accentuated percentage stenosis. However the lumen cross-sectional area was preserved only at the lower dose point. Delayed irradiation at any dose did not influence the restenosis process.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: *Angioplasty, Balloon,Animals,Arterial Occlusive Diseases/etiology,Disease Models, Animal,Dose-Response Relationship, Radiation,Femoral Artery/*radiation effects/*surgery,Hypercholesterolemia/complications/*therapy,Male,Postoperative Complications/etiology,Rabbits,Radiotherapy Dosage,Time Factors,Treatment Outcome,Tunica Intima/radiation effects/surgery,Tunica Media/radiation effects/surgery,*X-Ray Therapy
URI: http://olympias.lib.uoi.gr/jspui/handle/123456789/21658
ISSN: 1522-1865
Link: http://www.ncbi.nlm.nih.gov/pubmed/12479912
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Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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