Fine-needle aspiration of secondary malignancies of the penis: a report of three cases (Journal article)

Tsanou, E./ Sintou-Mantela, E./ Pappa, L./ Grammeniatis, E./ Malamou-Mitsi, V.


Metastatic malignancy to the penis is an uncommon clinicopathologic entity, with only 300 cases reported since 1870. Of the reported cases, 75% were secondary to genitourinary primary tumors. Priapism is the most frequent symptom, although dysuria, ulceration, and node formation have also been described. We report three cases of penile metastatic involvement from primary tumors in the urinary bladder (two cases) and prostate (one case), respectively. Fine-needle aspiration (FNA) cytology from the penile nodules was performed in each case. The smears in all cases were highly cellular, and atypical neoplastic cells were observed singly, in clusters, or in papillary formations. The cells were pleomorphic with hyperchromatic nuclei and prominent nucleoli. Immunocytochemistry was performed for keratin 8 and 18 and prostatic-specific antigen (PSA). In conclusion, although it has rarely been used as a diagnostic tool, FNA of the penis can be proved effective and safe in diagnosing a suspected secondary malignancy.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: Aged,*Biopsy, Fine-Needle,Carcinoma, Transitional Cell/chemistry/*secondary/therapy,Combined Modality Therapy,Humans,Immunohistochemistry,Keratin-7,Keratins/analysis,Male,Middle Aged,Penile Neoplasms/chemistry/*secondary,Prostate-Specific Antigen/analysis,Prostatic Neoplasms/chemistry/*pathology/therapy,Tumor Markers, Biological/analysis,Urinary Bladder Neoplasms/chemistry/*pathology/therapy
URI: http://olympias.lib.uoi.gr/jspui/handle/123456789/21557
ISSN: 8755-1039
Link: http://www.ncbi.nlm.nih.gov/pubmed/14506678
http://onlinelibrary.wiley.com/store/10.1002/dc.10354/asset/10354_ftp.pdf?v=1&t=h0f0ykpu&s=bce06a9990139a1b96757c859f6c381fb89f460f
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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