Galectin-2 (LGALS2) 3279C/T polymorphism may be independently associated with diastolic blood pressure in patients with rheumatoid arthritis (Journal article)

Panoulas, V. F./ Douglas, K. M./ Smith, J. P./ Metsios, G. S./ Elisaf, M. S./ Nightingale, P./ Kitas, G. D.

The galectin-2 (LGALS2) 3279 C/T single nucleotide polymorphism (SNP) has recently been associated with myocardial infarction (MI). Although hypertension, a very prevalent entity in rheumatoid arthritis (RA), is one of the greatest risk factors for MI, the possible association of LGALS2 3279 C/T and hypertension has not been investigated. We genotyped 386 RA patients, 272 hypertensives and 114 normotensives. Diastolic blood pressure (DBP) was significantly lower in TT compared to CC homozygotes (-4.11 mmHg, p = 0.044) even when adjusted for multiple confounders (-4.28 mmHg, p = 033). Further studies are required to replicate the potential association of LGALS2 3279 C/T with DBP, and examine whether this SNP could be used as a marker of increased risk for future cardiovascular events in RA populations.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: Aged,Arthritis, Rheumatoid/complications/*genetics,Blood Pressure,Female,Galectin 2/*genetics,Genotype,Humans,Hypertension/complications/*genetics,Male,Middle Aged,Myocardial Infarction/complications/*genetics,*Polymorphism, Single Nucleotide,Prevalence,Risk Factors
URI: https://olympias.lib.uoi.gr/jspui/handle/123456789/21467
ISSN: 1525-6006
Link: http://www.ncbi.nlm.nih.gov/pubmed/19330599
http://informahealthcare.com/doi/abs/10.1080/10641960802621267
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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