Giardia lamblia intestinalis: a new pathogen with possible link to Kikuchi-Fujimoto disease. An additional element in the disease jigsaw (Journal article)

Charalabopoulos, K./ Charalabopoulos, A./ Papadopoulou, C. H./ Papalimneou, V.

A 16-year-old Caucasian girl of Albanian origin was admitted to the hospital complaining of intermittent fever (38 degrees C) for a week, nausea, vomiting, and abnormal laboratory findings (elevated serum aminotransferases levels AST/ALT 77/40 U/l and erythrocyte sedimentation rate 80 mm/first hour, as well as leukopenia 2.5 x 10(3)/mm3), which were found in a blood examination. Physical examination revealed slight hepatomegaly and splenomegaly, as well as cervical and axillary lymphadenopathy. A diagnostic open lymph node biopsy was performed and Kikuchi-Fujimoto disease (KFD) was established based on the characteristic histological pattern. Other abnormal laboratory findings were C-reactive protein 6.8 mg/dl and serum lactate dehydrogenase 900 U/l. Her history included a diarrhoea syndrome 2 months before the present admission, during the summer holidays, for which she was treated with metronidazole. At that time, characteristic cysts of giardia lamblia intestinalis were observed in the stools. Herein, we present this case hypothesising that the protozoal infection caused by the giardia lamblia intestinalis was probably triggering an immune response leading to KFD. The patient's age in combination with this firstly reported protozoal pathogen, as a triggering agent leading to KFD, consist a very interesting originality. Additionally, some review data is also given.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: Adolescent,Animals,Antiprotozoal Agents/*therapeutic use,C-Reactive Protein/analysis,Female,Giardia lamblia,Giardiasis/*complications,Histiocytic Necrotizing Lymphadenitis/drug therapy/*parasitology/pathology,Humans,Immunohistochemistry,Lymph Nodes/pathology,Metronidazole/*therapeutic use
URI: https://olympias.lib.uoi.gr/jspui/handle/123456789/21378
ISSN: 1368-5031
Link: http://www.ncbi.nlm.nih.gov/pubmed/15646421
http://onlinelibrary.wiley.com/store/10.1111/j.1742-1241.2004.00130.x/asset/j.1742-1241.2004.00130.x.pdf?v=1&t=h0c0vzui&s=97c9b2b13eea77eca36c087edb31b6702366c031
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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