Glycogen autophagy (Journal article)

Kotoulas, O. B./ Kalamidas, S. A./ Kondomerkos, D. J.


Glycogen autophagy, which includes the sequestration and degradation of cell glycogen in the autophagic vacuoles, is a selective process under conditions of demand for the massive hepatic production of glucose, as in the postnatal period. It represents a link between autophagy and glycogen metabolism. The formation of autophagic vacuoles in the hepatocytes of newborn animals is spatially and biochemically related to the degradation of cell glycogen. Many molecular elements and signaling pathways including the cyclic AMP/cyclic AMP-dependent protein kinase and the phosphoinositides/TOR pathways are implicated in the control of this process. These two pathways may converge on the same target to regulate glycogen autophagy.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: Animals,Animals, Newborn,*Autophagy,Female,Hepatocytes/*metabolism/ultrastructure,Humans,Liver Glycogen/*metabolism,Male,Rats,Vacuoles/physiology/ultrastructure
URI: http://olympias.lib.uoi.gr/jspui/handle/123456789/21356
ISSN: 1059-910X
Link: http://www.ncbi.nlm.nih.gov/pubmed/15287014
http://onlinelibrary.wiley.com/store/10.1002/jemt.20046/asset/20046_ftp.pdf?v=1&t=h1ymhv29&s=6fb96ca32c558de808283d3fa9817c5506de28b2
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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