Glycogen autophagy in newborn rat hepatocytes (Journal article)

Kalamidas, S. A./ Kotoulas, O. B.

Glycogen autophagy in newborn rat hepatocytes was studied by using enzyme determinations and electron microscopy. Cyclic AMP induced glycogen autophagy in these cells. Glycogen-hydrolyzing acid glucosidase activity increased whereas acid mannose 6-phosphatase activity decreased in the liver of these animals. Parenteral glucose, which prevents postnatal glucagon secretion and tissue cyclic AMP elevation, and propranolol which antagonizes cyclic AMP, inhibited glycogen autophagy. Glucosidase activity decreased and phosphatase activity increased. These findings raise the possibility that cyclic AMP-induced autophagic mechanisms in newborn rat hepatocytes are associated with changes in the activity of acid mannose 6-phosphatase.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: Animals,Animals, Newborn,Cyclic AMP/metabolism,Glucosidases/metabolism,Hepatocytes/enzymology/*metabolism/ultrastructure,Liver Glycogen/*metabolism,Microscopy, Electron,Phosphoric Monoester Hydrolases/metabolism,Rats,Rats, Wistar,Tissue Fixation
ISSN: 0213-3911
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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