Glycogen autophagy in the liver and heart of newborn rats. The effects of glucagon, adrenalin or rapamycin (Journal article)

Kondomerkos, D. J./ Kalamidas, S. A./ Kotoulas, O. B./ Hann, A. C.


The effects of glucagon, adrenalin or rapamycin on glycogen autophagy in the liver and heart of newborn rats were studied using biochemical determinations and electron microscopy. Glucagon or adrenalin increased autophagic activity in the hepatocytes and myocardiocytes, glycogen-hydrolyzing acid glucosidase activity in the liver and heart and degradation of glycogen inside the autophagic vacuoles. Glucagon or adrenalin also increased the maltose-hydrolyzing acid glucosidase activity in the liver, but not in the heart. Similar effects were produced in the newborn heart by rapamycin. These observations support previous studies suggesting that the cellular machinery which controls glycogen autophagy in the liver and heart of newborn animals, is regulated by the cyclic AMP and the mTOR pathways.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: Animals,Animals, Newborn,Autophagy/*drug effects,Epinephrine/pharmacology,Female,Glucagon/pharmacology,Glycogen/*metabolism,Heart/drug effects,Hepatocytes/drug effects/metabolism/ultrastructure,Liver/drug effects/*metabolism,Liver Glycogen/metabolism,Microscopy, Electron,Myocardium/*metabolism,Myocytes, Cardiac/drug effects/metabolism/ultrastructure,Pregnancy,Rats,Rats, Wistar,Sirolimus/pharmacology
URI: http://olympias.lib.uoi.gr/jspui/handle/123456789/21352
ISSN: 0213-3911
Link: http://www.ncbi.nlm.nih.gov/pubmed/15944916
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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