Guillain-Barre syndrome in northwest Greece (Journal article)

Markoula, S./ Giannopoulos, S./ Sarmas, I./ Tzavidi, S./ Kyritsis, A. P./ Lagos, G.


OBJECTIVES: We present the epidemiological and clinical-laboratory features of Guillain-Barre syndrome (GBS) in northwest Greece over a 9.5-year period. MATERIALS AND METHODS: We studied all the patients with GBS who were admitted to our neurology inpatient service from January 1996 to May 2005 and compared them with previously published series. RESULTS: Forty-six patients were hospitalized during this period. The average crude incidence rate was 1.22/100,000 populations per year, and males were more susceptible than females. There was a spring clustering, as 52.17% presented the syndrome during spring. The axonal type of GBS was recorded in 13.04% of the patients. The most frequent presenting symptom was dysesthetic numbness (52.17%). A large number of patients (56.52%) had up to three times the elevation of liver function values that resolved in a few weeks. Most patients had an excellent recovery and no deaths were recorded. CONCLUSIONS: In our series, there was no difference in the incidence rate and subtypes of GBS but there was a significant seasonality with spring clustering. A transient elevation of transaminases of undetermined etiology was noted in more than a half of our patients. Although seven patients (15.21%) had significant neurologic sequelae, no deaths occurred.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: Adolescent,Adult,Age Distribution,Aged,Disability Evaluation,Female,Greece/epidemiology,Guillain-Barre Syndrome/complications/*epidemiology/metabolism,Humans,Incidence,Male,Middle Aged,Retrospective Studies,Seasons,Sex Distribution
URI: http://olympias.lib.uoi.gr/jspui/handle/123456789/21316
ISSN: 0001-6314
Link: http://www.ncbi.nlm.nih.gov/pubmed/17295711
http://onlinelibrary.wiley.com/store/10.1111/j.1600-0404.2006.00731.x/asset/j.1600-0404.2006.00731.x.pdf?v=1&t=h0b2d1m3&s=f5b04baed8618670b21942c3ac70f6ca0cf64565
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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