Helicobacter pylori infection in children: potential clues to pathogenesis (Journal article)

Mitchell, H. M./ Bohane, T. D./ Tobias, V./ Bullpitt, P./ Daskalopoulos, G./ Carrick, J./ Mitchell, J. D./ Lee, A.

Children (227) undergoing endoscopy for upper gastrointestinal symptoms were investigated for the presence of Helicobacter pylori infection. The histological response to H. pylori infection and the presence of antral nodularity and peptic ulceration were noted. Symptomatic adults (258) undergoing endoscopy were also investigated for the presence of nodularity. H. pylori infection was detected histologically in 32 of 227 (14.1%) children. Of those children infected with H. pylori, half (50%) had antral nodular gastritis. Of 139 H. pylori-positive adults 22 (15.8%) showed nodularity. The active component of the histological response was found to be minimal or lacking in the majority of children infected with H. pylori. Twelve of the 227 children (5.3%) had peptic ulcer disease. Of these, nine were duodenal and three gastric ulcers. Of the nine children with duodenal ulceration three (33%) were infected with H. pylori. As a result of this study we conclude that (a) although antral nodularity occurs more frequently in children it is not exclusive to childhood, (b) the polymorphonuclear response in children is less than that reported in adults, and (c) peptic ulcer disease is rare in children and the present study would suggest that in children it is less frequently associated with H. pylori infection than in adults.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: Acute Disease,Adolescent,Adult,Age Factors,Aged,Child,Child, Preschool,Chronic Disease,Duodenum/microbiology/pathology,Female,Gastritis/epidemiology/microbiology/pathology,Gastroscopy,Helicobacter Infections/*epidemiology/microbiology/pathology,*Helicobacter pylori,Humans,Immunoglobulin G/analysis,Incidence,Infant,Male,Middle Aged,Peptic Ulcer/epidemiology/microbiology/pathology,Prospective Studies,Stomach/microbiology/pathology
URI: https://olympias.lib.uoi.gr/jspui/handle/123456789/21282
ISSN: 0277-2116
Link: http://www.ncbi.nlm.nih.gov/pubmed/8450376
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

Files in This Item:
There are no files associated with this item.

 Please use this identifier to cite or link to this item:
  This item is a favorite for 0 people.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.