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Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/21269
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dc.contributor.authorKotsovolou, O.en
dc.contributor.authorIngelman-Sundberg, M.en
dc.contributor.authorLang, M. A.en
dc.contributor.authorMarselos, M.en
dc.contributor.authorOverstreet, D. H.en
dc.contributor.authorPapadopoulou-Daifoti, Z.en
dc.contributor.authorJohanson, I.en
dc.contributor.authorFotopoulos, A.en
dc.contributor.authorKonstandi, M.en
dc.date.accessioned2015-11-24T19:14:12Z-
dc.date.available2015-11-24T19:14:12Z-
dc.identifier.issn1878-4216-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/21269-
dc.rightsDefault Licence-
dc.subjectAnalysis of Varianceen
dc.subjectAnimalsen
dc.subjectAntidepressive Agents, Tricyclic/pharmacologyen
dc.subjectBlotting, Westernen
dc.subjectChromatography, High Pressure Liquiden
dc.subjectCytochrome P-450 CYP1A1/metabolismen
dc.subjectCytochrome P-450 Enzyme System/*metabolismen
dc.subjectDepressive Disorder/*enzymologyen
dc.subject*Disease Models, Animalen
dc.subjectDopamine/metabolismen
dc.subjectGlutathione/metabolismen
dc.subjectGlutathione Transferase/metabolismen
dc.subjectHypothalamus/drug effects/metabolismen
dc.subjectLiver/drug effects/*enzymologyen
dc.subjectMaleen
dc.subjectMianserin/analogs & derivatives/pharmacologyen
dc.subjectNorepinephrine/metabolismen
dc.subjectRatsen
dc.subjectRats, Sprague-Dawleyen
dc.titleHepatic drug metabolizing profile of Flinders Sensitive Line rat model of depressionen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.primary10.1016/j.pnpbp.2010.05.029-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/20595028-
heal.identifier.secondaryhttp://ac.els-cdn.com/S0278584610002137/1-s2.0-S0278584610002137-main.pdf?_tid=736125185e1b712fa65718cc4517fd86&acdnat=1333434658_c0d1d006bd6e36a99e2a52a18bb32c08-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate2010-
heal.abstractThe Flinders Sensitive Line (FSL) rat model of depression exhibits some behavioral, neurochemical, and pharmacological features that have been reported in depressed patients and has been very effective in screening antidepressants. Major factor that determines the effectiveness and toxicity of a drug is the drug metabolizing capacity of the liver. Therefore, in order to discriminate possible differentiation in the hepatic drug metabolism between FSL rats and Sprague-Dawley (SD) controls, their hepatic metabolic profile was investigated in this study. The data showed decreased glutathione (GSH) content and glutathione S-transferase (GST) activity and lower expression of certain major CYP enzymes, including the CYP2B1, CYP2C11 and CYP2D1 in FSL rats compared to SD controls. In contrast, p-nitrophenol hydroxylase (PNP), 7-ethoxyresorufin-O-dealkylase (EROD) and 16alpha-testosterone hydroxylase activities were higher in FSL rats. Interestingly, the wide spread environmental pollutant benzo(alpha)pyrene (B(alpha)P) induced CYP1A1, CYP1A2, CYP2B1/2 and ALDH3c at a lesser extend in FSL than in SD rats, whereas the antidepressant mirtazapine (MIRT) up-regulated CYP1A1/2, CYP2C11, CYP2D1, CYP2E1 and CYP3A1/2, mainly, in FSL rats. The drug also further increased ALDH3c whereas suppressed GSH content in B(alpha)P-exposed FSL rats. In conclusion, several key enzymes of the hepatic biotransformation machinery are differentially expressed in FSL than in SD rats, a condition that may influence the outcome of drug therapy. The MIRT-induced up-regulation of several drug-metabolizing enzymes indicates the critical role of antidepressant treatment that should be always taken into account in the designing of treatment and interpretation of insufficient pharmacotherapy or drug toxicity.en
heal.journalNameProg Neuropsychopharmacol Biol Psychiatryen
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
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