HLA-alloantigen associations in Greek patients with Sjogren's syndrome (Journal article)

Papasteriades, C. A./ Skopouli, F. N./ Drosos, A. A./ Andonopoulos, A. P./ Moutsopoulos, H. M.


The frequency of HLA-A, -B, and -DR alloantigens was studied in 46 patients with primary Sjogren's syndrome (pSS), 14 patients with secondary Sjogren's syndrome (sSS) and rheumatoid arthritis (RA), 26 classical RA patients without clinical or histologic evidence of Sjogren's syndrome (SS) and 172 normal controls. A statistically significant increase in the frequency of HLA-DR5 alloantigen was observed in the pSS patients, compared with the controls (P less than 0.007, corrected). No differences were detected between pSS patients with or without extraglandular manifestations, nor were any found between anti-Ro(SSA) positive and negative patients. The frequency of HLA-DR3 alloantigen (30%) was not significantly higher in our pSS population than in controls (25%), nor was that of -DR4 in the RA or the sSS patients. The results of the present study indicate that the 'SS susceptibility gene' in Greek patients is linked with the HLA-DR5 expression gene and they support the hypothesis that the fundamental pSS gene may belong to another locus.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: Arthritis, Rheumatoid/genetics,Autoantigens/analysis,Gene Frequency,Greece,HLA Antigens/*analysis,HLA-DR Antigens/analysis,Humans,Immunodiffusion,Immunoelectrophoresis,*RNA, Small Cytoplasmic,*Ribonucleoproteins,Sjogren's Syndrome/*genetics
URI: http://olympias.lib.uoi.gr/jspui/handle/123456789/21180
ISSN: 0896-8411
Link: http://www.ncbi.nlm.nih.gov/pubmed/3151145
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Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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