HLA-DR expression by labial minor salivary gland tissues in Sjogren's syndrome (Journal article)

Moutsopoulos, H. M./ Hooks, J. J./ Chan, C. C./ Dalavanga, Y. A./ Skopouli, F. N./ Detrick, B.


Minor salivary gland biopsy specimens from patients with Sjogren's syndrome (primary and secondary) and from normal controls were examined with the four step biotin-avidin-immunoperoxidase assay. The composition of the infiltrating cells was similar in patients with both primary and secondary Sjogren's syndrome, consisting primarily of T lymphocytes with predominance of T helper/inducer cells. B lymphocytes (Leu-14) were approximately 20-35% of the infiltrating lymphocytes, while only a few OKM1 (monocytes/macrophages) cells and Leu-7+ (natural killer; NK) cells were observed. The majority of infiltrating lymphocytes expressed HLA-DR antigens. In the biopsy specimens of the controls there were no infiltrates; the scattered lymphocytes, however, were also predominantly T lymphocytes. Finally, the glandular epithelial cells (ducts and acini) were inappropriately expressing HLA-DR antigens, in contrast with controls where minimal HLA-DR expression was found.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: Adult,Aged,Female,HLA-DR Antigens,Histocompatibility Antigens Class II/*analysis,Humans,Immunoenzyme Techniques,Lymphocytes/immunology,Male,Middle Aged,Salivary Glands/*immunology,Salivary Glands, Minor/*immunology/pathology,Sjogren's Syndrome/*immunology/pathology
URI: http://olympias.lib.uoi.gr/jspui/handle/123456789/21177
ISSN: 0003-4967
Link: http://www.ncbi.nlm.nih.gov/pubmed/3527087
http://ard.bmj.com/content/45/8/677.full.pdf
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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