Hypothalamic-pituitary-adrenal axis function in Sjogren's syndrome: mechanisms of neuroendocrine and immune system homeostasis (Journal article)

Johnson, E. O./ Kostandi, M./ Moutsopoulos, H. M.


To date, evidence suggests that rheumatic diseases are associated with hypofunctioning of the hypothalamic-pituitary-adrenal (HPA) axis. Sjogren's syndrome (SS), the second most common autoimmune disorder, is characterized by diminished lacrimal and salivary gland secretion. To examine HPA axis activity in SS patients, the adrenocorticotropin (ACTH) response to ovine corticotropin-releasing factor (oCRH) was used as a direct measure of corticotrophic function, and the plasma cortisol response to the ACTH released during oCRH stimulation as an indirect measure of adrenal function. Significantly lower basal ACTH and cortisol levels were found in patients with SS and were associated with a blunted pituitary and adrenal response to oCRH compared to normal controls. Fibromyalgia (FM) patients demonstrated elevated evening basal ACTH and cortisol levels and a somewhat exaggerated peak, delta, and net integrated ACTH response to oCRH. A subgroup of SS patients also met the diagnostic criteria for FM and demonstrated a pituitary-adrenal response that was intermediate to SS and FM. These findings suggest not only adrenal axis hypoactivity in SS and FM patients, but also that varying patterns of adrenal and thyroid axes dysfunction may exist in patients with different rheumatic diseases.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: Animals,Homeostasis/*immunology,Humans,Hypothalamo-Hypophyseal System/*immunology,Neuroimmunomodulation/*immunology,Pituitary-Adrenal System/*immunology,Sjogren's Syndrome/*immunology
URI: http://olympias.lib.uoi.gr/jspui/handle/123456789/21080
ISSN: 0077-8923
Link: http://www.ncbi.nlm.nih.gov/pubmed/17192555
http://onlinelibrary.wiley.com/store/10.1196/annals.1366.018/asset/annals.1366.018.pdf?v=1&t=h0uos7p2&s=e7dc33a64a90074f468623fe578305502859a37e
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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