Immune thrombocytopenia attributed to brucellosis and other mechanisms of Brucella-induced thrombocytopenia (Journal article)

Pappas, G./ Kitsanou, M./ Christou, L./ Tsianos, E.

Thrombocytopenia often complicates the course of acute brucellosis, mainly due to bone marrow suppression or hypersplenism. Immune thrombocytopenia is also reported in brucellosis, resulting usually in massive thrombocytopenia, purpura, and spontaneous hemorrhage. We describe a case of acute brucellosis in an 85-year old woman, who presented with fever, purpuric skin lesions, anemia, and rhinorrhagia. The absolute platelet count was 1000/microL. Direct and indirect Coombs tests were positive, and a cold-agglutinin was detected. The patient was diagnosed as suffering from brucellosis on the basis of a strongly positive serologic reaction and was treated with doxycycline, streptomycin, and a short course of corticosteroids, with a rapid rise in platelet number.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: Acute Disease,Adrenal Cortex Hormones/therapeutic use,Aged,Aged, 80 and over,Anti-Bacterial Agents/therapeutic use,Brucella,Brucellosis/blood/*complications/drug therapy,Coombs' Test,Doxycycline/therapeutic use,Female,Humans,Platelet Count,Purpura, Thrombocytopenic, Idiopathic/blood/drug therapy/*microbiology,Streptomycin/therapeutic use
URI: https://olympias.lib.uoi.gr/jspui/handle/123456789/21014
ISSN: 0361-8609
Link: http://www.ncbi.nlm.nih.gov/pubmed/14978693
http://onlinelibrary.wiley.com/store/10.1002/ajh.10473/asset/10473_ftp.pdf?v=1&t=h0p16w8m&s=5a65ca1867c3956e1e3b0dbe0c27b73260af12de
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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