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  4. Τμήμα Ιατρικής
  5. Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ
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Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/21002
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dc.contributor.authorStefanaki, K.en
dc.contributor.authorRontogiannis, D.en
dc.contributor.authorVamvouka, C.en
dc.contributor.authorBolioti, S.en
dc.contributor.authorChaniotis, V.en
dc.contributor.authorSotsiou, F.en
dc.contributor.authorVlychou, M.en
dc.contributor.authorDelidis, G.en
dc.contributor.authorKakolyris, S.en
dc.contributor.authorGeorgoulias, V.en
dc.contributor.authorKanavaros, P.en
dc.date.accessioned2015-11-24T19:12:01Z-
dc.date.available2015-11-24T19:12:01Z-
dc.identifier.issn0250-7005-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/21002-
dc.rightsDefault Licence-
dc.subjectCarcinoma, Small Cell/*pathologyen
dc.subjectCyclin-Dependent Kinase Inhibitor p21en
dc.subjectCyclins/*analysisen
dc.subjectEnzyme Inhibitors/*analysisen
dc.subjectHumansen
dc.subjectImmunohistochemistry/methodsen
dc.subjectLung Neoplasms/*pathologyen
dc.subjectNeoplasm Proteins/analysisen
dc.subject*Nuclear Proteinsen
dc.subjectProto-Oncogene Proteins/*analysisen
dc.subjectProto-Oncogene Proteins c-bcl-2/*analysisen
dc.subjectProto-Oncogene Proteins c-mdm2en
dc.subjectTumor Suppressor Protein p53/*analysisen
dc.titleImmunohistochemical detection of bcl2, p53, mdm2 and p21/waf1 proteins in small-cell lung carcinomasen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/9673391-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate1998-
heal.abstractThirty-one cases of small cell lung carcinomas (SCLC) were investigated by immunohistochemistry for the expression of bcl-2. P53 and the wild-type (wt) p53-induced proteins mdm2 and p21/waf1. Bcl-2 protein was detected in 24/31 cases of SCLC(77%) and p53 protein in 13/31 cases (42%). No correlation was found between histological subtype of SCLC and bcl-2 or p53 expression. Comparison between bcl-2 and p53 expression showed that 14/31 cases (45%) were only bcl-2 positive, 3/31 (11%) were only p53 positive, 10/31 (32%) were positive for both proteins and 4/31 (13%) were negative for both proteins. Mdm2 protein was detected in 2/32 SCLC which were also p53 positive. P21 protein was detected in 6/32 SCLC. Four of the p21 positive SCLC were negative for both p53 and mdm2, and two were positive for both p53 and mdm2 proteins. The significant expression of bcl-2 protein in SCLC suggests that bcl-2 may be involved in the pathogenesis of most SCLC by inhibiting apoptosis during neoplastic transformation. The expression of p53 protein in SCLC is likely to be related to underlying p53 gene mutations since these genetic alterations are very frequent in SCLC. This can be supported by our findings that 11/13 p53 positive SCLC were mdm2 and p21 negative. The two cases with p53+/mdm2+/p21+ phenotype may represent tumours with wt p53 gene and p53 protein immunoexpression due to binding to mdm2 protein. The four cases with p53-/mdm2-/p21+ phenotype may represent tumours with p53-independent p21 protein expression. Coexpression of p53 and bcl-2 proteins in a proportion of SCLC suggests that in these tumours p53 does not maintain its suppressive effect on bcl-2 expression as has been reported in vitro. Further studies at the DNA and RNA level are required to clarify the involvement of bcl-2, p53, mdm2 and wafl genes in SCLC pathogenesis.en
heal.journalNameAnticancer Resen
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
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