Impact of renin-angiotensin-aldosterone system genes on the treatment response of patients with hypertension and metabolic syndrome (Journal article)

Milionis, H. J./ Kostapanos, M. S./ Vakalis, K./ Theodorou, I./ Bouba, I./ Kalaitzidis, R./ Georgiou, I./ Elisaf, M. S./ Siamopoulos, K. C.

OBJECTIVE: To evaluate the influence of clinical, biochemical and genetic markers on the response to antihypertensive treatment in patients with essential hypertension and the metabolic syndrome (MetS). METHODS: Measurements of anthropometric indices, blood pressure (BP), and metabolic parameters were obtained from the medical records of 132 (77 women) newly diagnosed, untreated hypertensive patients. Renin-angiotensin-aldosterone system (RAAS) genes polymorphisms (including ACE I/D, angiotensinogen M235T, angiotensin II type 1 receptor [AT1-receptor] A1166C) were determined. Response to treatment was defined as BP less than 140/90 mmHg. RESULTS: Patients with MetS (n=60) had higher systolic BP and pulse pressure and a more atherogenic lipid profile than patients without MetS. The frequencies of the ACE and the AT1-receptor gene polymorphisms were similar between patients with and without MetS. Response to treatment was positively associated with pulse pressure, and the presence of the C allele as well as the AC genotype of the AT1-receptor gene and inversely with age after adjustment for confounding factors. CONCLUSIONS: RAAS genes distribution does not differ between hypertensive patients with and without the MetS. Higher baseline pulse pressure levels, the presence of the C allele and/or the AC genotype may be in favour of a better response to structured antihypertensive treatment in patients with MetS. However, these findings need to be evaluated in future studies.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: Demography,Female,Genotype,Greece/epidemiology,Humans,Hypertension/*complications/*drug therapy/genetics,Male,Metabolic Syndrome X/*complications/*drug therapy/epidemiology/genetics,Middle Aged,Polymorphism, Genetic,Prevalence,Regression Analysis,Renin-Angiotensin System/*genetics,Treatment Outcome
ISSN: 1470-3203
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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