Irinotecan/fluorouracil/leucovorin or the same regimen followed by oxaliplatin/fluorouracil/leucovorin in metastatic colorectal cancer (Journal article)

Kalofonos, H. P./ Papakostas, P./ Makatsoris, T./ Papamichael, D./ Vourli, G./ Xanthakis, I./ Aravantinos, G./ Papadimitriou, C./ Pentheroudakis, G./ Varthalitis, I./ Samelis, G./ Syrigos, K. N./ Xiros, N./ Stavropoulos, M./ Kosmidis, P./ Christodoulou, C./ Linardou, H./ Skondra, M./ Pectasides, D./ Economopoulos, T./ Fountzilas, G.

BACKGROUND: This study reports the long-term follow-up of patients with metastatic colorectal cancer (CRC) participating in a randomised phase II study that compared the efficacy and toxicity of the combination of irinotecan (IRI), fluorouracil (FU) with leucovorin (LV) (arm A) versus sequential chemotherapy with IRI plus FU/LV followed by oxaliplatin (OXA) plus FU/LV (arm B) as first line therapy. MATERIALS AND METHODS: Intent-to-treat analysis was performed on 417 patients (211 in arm A and 206 in arm B). Treatment schedules of weekly IRI 80 mg/m(2) or OXA 45 mg/m(2) plus LV 200 mg/m(2) immediately followed by intravenous bolus FU 450 mg/m(2) for 6 weeks were followed by a 2-week rest period. Treatment continued for 4 cycles. Patients in arm A were treated with IRI/FU/LV for 4 cycles, while patients in arm B were initially treated with IRI/FU/LV for 2 cycles followed by sequential administration of 2 cycles of OXA/FU/LV. RESULTS: No significant difference emerged in overall response rate or overall survival. There was a difference in progression-free survival (median, 7.3 versus 8.2 months, p=0.040) in favour of arm B. Toxicity profiles were similar in both arms. CONCLUSION: IRI/FU/LV and IRI/FU/LV followed by OXA/FU/LV showed comparable activity with a manageable toxicity profile.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: Adenocarcinoma/*drug therapy,Adult,Aged,Aged, 80 and over,Antineoplastic Combined Chemotherapy Protocols/adverse effects/*therapeutic use,Camptothecin/administration & dosage/adverse effects/analogs & derivatives,Colorectal Neoplasms/*drug therapy,Female,Fluorouracil/administration & dosage/adverse effects,Follow-Up Studies,Humans,Leucovorin/administration & dosage/adverse effects,Male,Middle Aged,Organoplatinum Compounds/administration & dosage/adverse effects
URI: https://olympias.lib.uoi.gr/jspui/handle/123456789/20625
ISSN: 1791-7530
Link: http://www.ncbi.nlm.nih.gov/pubmed/21036759
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

Files in This Item:
There are no files associated with this item.


 Please use this identifier to cite or link to this item:
https://olympias.lib.uoi.gr/jspui/handle/123456789/20625
  This item is a favorite for 0 people.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.