Labial salivary gland immunopathology in Sjogren's syndrome (Journal article)

Dalavanga, Y. A./ Drosos, A. A./ Moutsopoulos, H. M.

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dc.contributor.authorDalavanga, Y. A.en
dc.contributor.authorDrosos, A. A.en
dc.contributor.authorMoutsopoulos, H. M.en
dc.rightsDefault Licence-
dc.subjectSalivary Glands/*immunologyen
dc.subjectSalivary Glands, Minor/*immunology/pathologyen
dc.subjectSjogren's Syndrome/*immunology/pathologyen
dc.titleLabial salivary gland immunopathology in Sjogren's syndromeen
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.abstractThe cellular composition of the salivary gland infiltrates in primary Sjogren's syndrome and the presence of lymphokines were evaluated using the Avidin-Biotin-Peroxidase technique in 10 biopsies from patients with Sjogren's syndrome. The 10 specimens were stained with monoclonal antibodies (MoAb) against T-lymphocytes (Leu-4), Monocytes/Macrophages (M phi) (Leu-M3 and OKM1), Natural Killer cells (NK) (Leu-11 and Leu-7), class II MHC antigens (anti HLA-DR and OKIa1, anti Leu-10), Interleukin-2 (anti IL-2), IL-2 Receptor (anti IL-2 receptor) and Interferon gamma (IFN-gamma) (supernatant fluid from hybridoma cell line producing MoAb to IFN-gamma). The predominant cell was the T-helper/inducer lymphocyte. T-helper/T-suppressor ratio ranged from 1/1 to 10/1. Only few M phi were observed while NK cells were rare. More than 50% (50-100%) of the infiltrating cells were HLA-DR positive while epithelial cells were positive from 40-90% in all but two cases in which the positivity was 10%. The infiltrating cells were also positive for Leu-10 antigen (40-95%) in contrast to the epithelial cells. Both infiltrating and epithelial cells were reacting with anti IL-2 MoAb in high percentages (50-100%), while none of the infiltrating cells expressed IL-2 receptor. Finally, 40-100% of the infiltrating cells were IFN-gamma positive. Our data indicate that the salivary gland lesion in Sjogren's syndrome, is the result of an immune process in which T-lymphocytes predominate producing lymphokines, while the epithelial cells by expressing class II MHC molecules, occupy an important part of the picture.en
heal.journalNameScand J Rheumatol Supplen
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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