Langerhans cells and lymphocyte subsets in human gastrointestinal carcinomas. An immunohistological study on frozen sections (Journal article)

Papadimitriou, C. S./ Datseris, G./ Costopoulos, J. S./ Bai, M. K./ Ioachim-Velogianni, E./ Katsouyannopoulos, V.

In an immunohistochemical study of 38 human gastric and 40 human colonic carcinomas Langerhans cells, suppressor and helper lymphocytes were identified on frozen sections by using anti-CD1, anti-CD8 and anti-CD4 monoclonal antibodies. Tumours were divided into those with few (< 3 per high power field) and those with many (> 3 per high power field) Langerhans cells as well as into those with high number of CD4 and CD8 cells (> 30 per high power field). No significant difference in the number of Langerhans cells regarding histologic types, degree of differentiation and metastatic/non-metastatic groups of either gastric or colonic carcinomas was found. On the contrary the numbers of Langerhans cells related significantly (p < 0.05) to density of T-cell and especially CD4 cell infiltrations of gastric and colonic carcinomas. This finding supports the role of Langerhans cells as antigen presenting cells and their involvement in T-cell activation against neoplastic cells of human gastrointestinal carcinomas.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: Adult,Aged,Aged, 80 and over,Antibodies, Monoclonal,Carcinoma/chemistry/*pathology,Colorectal Neoplasms/chemistry/*pathology,Female,Humans,Langerhans Cells/*pathology,Male,Middle Aged,S100 Proteins/analysis,Stomach Neoplasms/chemistry/*pathology,T-Lymphocytes, Helper-Inducer/*pathology,T-Lymphocytes, Regulatory/*pathology
ISSN: 0344-0338
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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