Long-term evaluation of rabbit peripheral nerve repair with end-to-side neurorrhaphy in rabbits (Journal article)

Zhang, Z./ Johnson, E. O./ Vekris, M. D./ Zoubos, A. B./ Bo, J./ Beris, A. E./ Soucacos, P. N.


This study was designed to quantitatively assess long-term end-to-side neurorrhaphy in rabbits. The cut right ulnar nerve was repaired and sutured to the median nerve, in which a perineurial window was created in an end-to-side fashion 3 cm above the elbow joint. Both the extent of the reinnervation and the integrity of the intact donor nerve were evaluated in 36 rabbits randomly treated with fresh or delayed nerve repair. Evaluations included motor nerve conduction velocity (MNCV), dry muscle weight (DMW), and histological examinations at 9 and 12 months postoperatively. The recovery rates of MNCV were 90.1% and 92.8% for the ulnar nerve, and 95.7% and 96.8% for the median nerve, compared to intact contralateral nerves at 9 and 12 months, respectively. MNCV was not detectable for the ulnar nerve in control animals, while it was normal for the median nerve. Recoveries of flexor carpi ulnaris dry muscle weight of about 90.7% and 94.5% were observed at 9 and 12 months postoperatively, respectively. However, muscle mass measurements revealed a recovery of only 31.3% and 27% for control groups at 9 and 12 months postoperatively. The differences between experimental groups and control groups were statistically significant (P < 0.01). Neurofilament and silver stains showed numerous sprouting axons originating from the median nerve to the ulnar nerve. The results indicate that end-to-side neurorrhaphy could induce axonal sprouting from the main nerve trunk of upper limbs in rabbits, leading to useful functional recovery.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: Animals,Neurosurgical Procedures/methods,Peripheral Nerves/anatomy & histology/physiology/*surgery,Rabbits,Time Factors
URI: http://olympias.lib.uoi.gr/jspui/handle/123456789/20340
ISSN: 0738-1085
Link: http://www.ncbi.nlm.nih.gov/pubmed/16628745
http://onlinelibrary.wiley.com/store/10.1002/micr.20237/asset/20237_ftp.pdf?v=1&t=h0jo2g8a&s=a9003a32d3a7590c1dd54aff125ce853a44fc29d
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

Files in This Item:
File Description SizeFormat 
Zhang-2006-Long-term evaluation.pdf258.72 kBAdobe PDFView/Open    Request a copy



 Please use this identifier to cite or link to this item:
http://olympias.lib.uoi.gr/jspui/handle/123456789/20340
  This item is a favorite for 0 people.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.