1. Repository of OAI
  2. ΑΠΟΘΕΤΗΡΙΟ "ΟΛΥΜΠΙΑΣ"
  3. Σχολή Επιστημών Υγείας
  4. Τμήμα Ιατρικής
  5. Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ
Ελληνικά   English  
Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/20260
Full metadata record
DC FieldValueLanguage
dc.contributor.authorPanoulas, V. F.en
dc.contributor.authorNikas, S. N.en
dc.contributor.authorSmith, J. P.en
dc.contributor.authorDouglas, K. M.en
dc.contributor.authorNightingale, P.en
dc.contributor.authorMilionis, H. J.en
dc.contributor.authorTreharne, G. J.en
dc.contributor.authorToms, T. E.en
dc.contributor.authorKita, M. D.en
dc.contributor.authorKitas, G. D.en
dc.date.accessioned2015-11-24T19:05:53Z-
dc.date.available2015-11-24T19:05:53Z-
dc.identifier.issn1468-2060-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/20260-
dc.rightsDefault Licence-
dc.subjectAdulten
dc.subjectAgeden
dc.subjectArthritis, Rheumatoid/complications/*geneticsen
dc.subjectCase-Control Studiesen
dc.subjectFemaleen
dc.subjectGalectin 2/geneticsen
dc.subjectGene Frequencyen
dc.subjectGenetic Predisposition to Diseaseen
dc.subjectGenotypeen
dc.subjectHumansen
dc.subjectLymphotoxin-alpha/*geneticsen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectMyocardial Infarction/etiology/*geneticsen
dc.subjectPhenotypeen
dc.subject*Polymorphism, Single Nucleotideen
dc.subjectRisk Factorsen
dc.titleLymphotoxin 252A>G polymorphism is common and associates with myocardial infarction in patients with rheumatoid arthritisen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.primary10.1136/ard.2007.082594-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/18230628-
heal.identifier.secondaryhttp://ard.bmj.com/content/67/11/1550-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate2008-
heal.abstractOBJECTIVE: Cardiovascular disease (CVD) is more prevalent and more likely to lead to death in patients with rheumatoid arthritis (RA). Single nucleotide polymorphisms of the genes for lymphotoxin-A (LT-A) and its regulatory protein galectin-2 (LGALS2) have been implicated as genetic risk factors for acute cardiovascular events in the general population: we hypothesised that their risk alleles/genotypes (a) may be more frequent among patients with RA compared with non-RA controls (thus explaining some of the increased CVD in RA), and (b) may be more frequent among patients with RA with prevalent CVD compared with patients with RA without CVD. METHODS: Genomic DNA samples were collected from 388 patients with RA and 399 local population controls without RA. LT-A gene intron 1 252A>G and LGALS2 intron 1 3279C>T single nucleotide polymorphisms were identified using real-time polymerase chain reaction and melting curve analysis. RESULTS: LT-A 252GG homozygotes were significantly more prevalent among patients with RA compared with controls (19.8% vs 11.8%, p = 0.002; OR(GG/GA,AA) = 1.85, 95% CI 1.25 to 2.75, p = 0.002). Patients with RA possessing LT-A 252 GG were significantly more likely to have had a myocardial infarction compared with those with LT-A 252 AA or GA (13% vs 5.5%, p = 0.02; adjusted OR(GG/GA,AA) = 3.03, 95% CI 1.2 to 7.68, p = 0.002). The frequency of LGALS2 polymorphisms was similar between RA and controls and was not associated with CVD among patients with RA. CONCLUSIONS: The LT-A 252GG genotype occurs more frequently among patients with RA than the general population. In RA, this genotype appears to associate with increased likelihood of suffering an myocardial infarction.en
heal.journalNameAnn Rheum Disen
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ

Show simple item record
Files in This Item:
There are no files associated with this item.
Show simple item record  


This item is licensed under a Creative Commons License Creative Commons