Treatment of neurobrucellosis: what is known and what remains to be answered (Journal article)

Pappas, G./ Akritidis, N./ Christou, L.

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dc.contributor.authorPappas, G.en
dc.contributor.authorAkritidis, N.en
dc.contributor.authorChristou, L.en
dc.rightsDefault Licence-
dc.subjectAnti-Bacterial Agents/*therapeutic useen
dc.subjectBrucellosis/complications/*drug therapyen
dc.subjectCeftriaxone/therapeutic useen
dc.subjectCentral Nervous System Bacterial Infections/*drug therapy/etiologyen
dc.subjectDoxycycline/*therapeutic useen
dc.subjectDrug Administration Scheduleen
dc.subjectRifampin/therapeutic useen
dc.subjectStreptomycin/therapeutic useen
dc.titleTreatment of neurobrucellosis: what is known and what remains to be answereden
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.abstractNeurological involvement is one of the most perplexing and diverse presentation complications of brucellosis, a worldwide prevalent zoonosis. This review presents the current knowledge available from medical literature and discusses the shortcomings of the existing data. A proposed regimen should include doxycycline and rifampicin and, with the benefit of doubt, ceftriaxone, since its high concentration in the cerebrospinal fluid may offer significant efficacy against the pathogen. Corticosteroids have been used in specialized situations. The use of streptomycin is discouraged owing to its questionable ability to penetrate into the cerebrospinal fluid and its potential neurotoxicity that may perplex the clinical presentation. Treatment duration should be individualized in the absence of an adequate cut-off index.en
heal.journalNameExpert Rev Anti Infect Theren
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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