Malignancies in beta-thalassemia patients: a single-center experience and a concise review of the literature (Journal article)

Benetatos, L./ Alymara, V./ Vassou, A./ Bourantas, K. L.


Thalassemia represents the world's most common monogenic disease, characterized by absence of or decreased globin chain production. The lifespan of thalassemia patients has been extended as a result of current supportive treatment. We report three cases of cancer (non-Hodgkin lymphoma, Hodgkin disease, and seminoma) in thalassemic patients. Factors that may contribute to the pathogenesis of cancer seem to be infections and iron overload through mechanisms of oxidative damage; immunomodulation or coexistence of the two diseases may only be coincidental.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: Adult,Female,Hodgkin Disease/complications/diagnosis/therapy,Humans,Lymphoma, Non-Hodgkin/complications/diagnosis/drug therapy,Male,Middle Aged,Neoplasms/*complications,Radiotherapy, Adjuvant,Seminoma/complications/diagnosis/therapy,Testicular Neoplasms/complications/diagnosis/therapy,beta-Thalassemia/*complications/diagnosis/*physiopathology/therapy
URI: http://olympias.lib.uoi.gr/jspui/handle/123456789/20225
ISSN: 1751-5521
Link: http://www.ncbi.nlm.nih.gov/pubmed/18333849
http://onlinelibrary.wiley.com/store/10.1111/j.1751-553X.2007.00929.x/asset/j.1751-553X.2007.00929.x.pdf?v=1&t=h2bog6dh&s=7eecd77d7c2dadb346c9d1c1f846199171014071
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

Files in This Item:
File Description SizeFormat 
Benetatos-2008-Malignancies in beta.pdf69.71 kBAdobe PDFView/Open    Request a copy



 Please use this identifier to cite or link to this item:
http://olympias.lib.uoi.gr/jspui/handle/123456789/20225
  This item is a favorite for 0 people.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.