Metabolic abnormalities in patients with primary open-angle glaucoma (Journal article)

Elisaf, M. S./ Kitsos, G./ Bairaktari, E./ Kalaitzidis, R./ Kalogeropoulos, C./ Psilas, K.

PURPOSE: Although there are few data on the underlying mechanisms of primary open-angle glaucoma (POAG), it has been suggested that metabolic diseases may play a role in the evolution of the disease. We carried out the present study to investigate the involvement of metabolic disturbances in POAG pathogenesis. MATERIAL/METHODS: Serum metabolic parameters were evaluated in 49 POAG patients without a known history of diabetes mellitus and 72 age and sex matched individuals without glaucoma (control group). RESULTS: Among the metabolic parameters examined, only fasting serum glucose and uric acid levels were found significantly higher in patients with glaucoma compared to the control population (117+/-17 mg/dl vs 105+/-11 mg/dl, p=0.05 and 6.2+/-1.9 mg/dl vs 5+/-1.2 mg/dl, p=0.006, respectively). Additionally, a considerably greater proportion of patients had disturbances of the carbohydrate metabolism and hyperuricemia. CONCLUSION: We conclude that disturbances of carbohydrate and uric acid metabolism could play a role in glaucoma damage and pathogenesis.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: Aged,Blood Glucose/analysis,Carbohydrate Metabolism,Diabetes Complications,Female,Glaucoma, Open-Angle/blood/*complications/etiology,Humans,Male,Metabolic Diseases/blood/*complications,Middle Aged,Risk Factors,Uric Acid/blood
ISSN: 1395-3907
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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