Molecular epidemiology of HPV infection using a clinical array methodology in 2952 women in Greece (Journal article)

Tsiodras, S./ Hatzakis, A./ Spathis, A./ Margari, N./ Meristoudis, C./ Chranioti, A./ Kyrgiou, M./ Panayiotides, J./ Kassanos, D./ Petrikkos, G./ Nasioutziki, M./ Loufopoulos, A./ Paraskevaidis, E./ Karakitsos, P.


The molecular epidemiology of human papillomavirus (HPV) infection in a sample of Greek women (n = 2952, mean age 42.2 +/- 13.3 years) was examined. HPV prevalence was 50.7% (95% confidence interval, 48.8-52.6). The most frequent HPV types were HPV 53, 51 and 66 (10.2%, 9.4% and 9.3%, respectively). HPV positivity was associated with age, age of sexual debut, number of sexual partners and duration of sexual relationship, while marriage or multiparity protected against infection (all p <0.001). Follow-up of this cohort will assist in predicting the effect of vaccination with the new HPV vaccines on future screening with HPV-based tests for cervical cancer.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: Adenocarcinoma/*epidemiology/pathology/virology,Adult,Aged,Carcinoma, Squamous Cell/*epidemiology/pathology/virology,Cervical Intraepithelial Neoplasia/epidemiology/pathology/virology,DNA, Viral/analysis,Female,Greece/epidemiology,Humans,Middle Aged,Molecular Epidemiology,Papillomaviridae/classification/*genetics,Papillomavirus Infections/diagnosis/*epidemiology/virology,Prevalence,Reagent Kits, Diagnostic,Tumor Virus Infections/*epidemiology/pathology/virology,Uterine Cervical Neoplasms/*epidemiology/pathology/virology,Vaginal Smears,Young Adult
URI: http://olympias.lib.uoi.gr/jspui/handle/123456789/19966
ISSN: 1469-0691
Link: http://www.ncbi.nlm.nih.gov/pubmed/21595788
http://onlinelibrary.wiley.com/store/10.1111/j.1469-0691.2011.03505.x/asset/j.1469-0691.2011.03505.x.pdf?v=1&t=h0p6r6bn&s=90346a2e93b094b6a31b90edcff359c35d69fa02
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