Mucosa-associated lymphoid tissue lymphoma of the lacrimal gland--a case report (Journal article)

Asproudis, I./ Gorezis, S./ Charonis, G. C./ Tolis, C./ Tsanou, E./ Agnantis, N. J.

MALT lymphoma of the ocular adnexa, an indolent B-cell lymphoma, rarely affects the lacrimal gland. The case of a 73-year-old man with ptosis and edema of the left upper eyelid, due to lacrimal gland swelling, is presented. Clinical evaluation and imaging examination led to excision biopsy. The mass histopathology, presenting organized lymphoid tissue, composed mainly of small B-cells, accompanied by immunophenotypic characteristics, was compatible with MALT lymphoma. Treatment with monoclonal antibody against CD-20 achieved a successful long-term disease control (4 years). The diagnostic approach is described and the pathological features and clinical signs of this rare entity are discussed, based on recent literature. The indolent clinical course of this lymphoma, either remaining localized or disseminating to other mucosal sites, is a distinct characteristic affecting prognosis.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: Aged,Anti-Inflammatory Agents/therapeutic use,Antibodies, Monoclonal/therapeutic use,Antibodies, Monoclonal, Murine-Derived,Antigens, CD20/metabolism,Biopsy,Follow-Up Studies,Humans,Immunohistochemistry,Lacrimal Apparatus/*pathology/radiography/surgery,Lymphoma, B-Cell, Marginal Zone/diagnosis/*pathology/radiography/surgery,Male,Methylprednisolone/therapeutic use,Time Factors,Tomography, X-Ray Computed,Treatment Outcome
URI: https://olympias.lib.uoi.gr/jspui/handle/123456789/19892
ISSN: 0258-851X
Link: http://www.ncbi.nlm.nih.gov/pubmed/16277031
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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