Multiple sclerosis, osteoporosis, and vitamin D (Journal article)

Sioka, C./ Kyritsis, A. P./ Fotopoulos, A.

Multiple sclerosis (MS) is associated with reduced bone mass and higher frequency of osteoporosis. Although high-dose short-term intravenous glucocorticoid regimens cause a decrease in bone formation, this effect is usually reversible and osteoporosis in MS patients may be independent of the short-term corticosteroid treatment. Clinical evidence suggests an important role of vitamin D as a modifiable risk factor in MS. Low circulating levels of vitamin D have been found in MS patients, especially during relapses, suggesting that vitamin D could be involved in the regulation of the clinical disease activity. Vitamin D mediates its function through a single vitamin D receptor (VDR). Polymorphisms of the VDR have major effects on vitamin D function and metabolism, and some VDR genotypes have been linked to osteoporosis and MS. Because the safety of high doses of vitamin D has not been established yet, vitamin D hasn't been used in enough doses to increase the serum level to a desired therapeutic target. Future clinical trials should determine the upper limit of vitamin D intake in order to achieve therapeutic benefit in MS patients.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: Adrenal Cortex Hormones/adverse effects,Animals,Bone and Bones/metabolism/physiopathology,Comorbidity,Female,Genetic Predisposition to Disease/genetics,Humans,Male,Multiple Sclerosis/*epidemiology/genetics/metabolism,Osteoporosis/*epidemiology/genetics/metabolism,Receptors, Calcitriol/genetics,Vitamin D/metabolism/therapeutic use,Vitamin D Deficiency/*epidemiology/genetics/metabolism
URI: https://olympias.lib.uoi.gr/jspui/handle/123456789/19858
ISSN: 1878-5883
Link: http://www.ncbi.nlm.nih.gov/pubmed/19800081
http://ac.els-cdn.com/S0022510X09008545/1-s2.0-S0022510X09008545-main.pdf?_tid=b4c05bb9960b4000da79ddc9a50d2b3a&acdnat=1332859900_58203cc616cfc3fc26797ed1f1592993
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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