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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Kanavaros, P. | en |
| dc.contributor.author | Ioannidou, D. | en |
| dc.contributor.author | Tzardi, M. | en |
| dc.contributor.author | Datseris, G. | en |
| dc.contributor.author | Katsantonis, J. | en |
| dc.contributor.author | Delidis, G. | en |
| dc.contributor.author | Tosca, A. | en |
| dc.date.accessioned | 2015-11-24T19:02:49Z | - |
| dc.date.available | 2015-11-24T19:02:49Z | - |
| dc.identifier.issn | 0344-0338 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/19838 | - |
| dc.rights | Default Licence | - |
| dc.subject | Herpesvirus 4, Human/*isolation & purification | en |
| dc.subject | Humans | en |
| dc.subject | Immunohistochemistry | en |
| dc.subject | In Situ Hybridization | en |
| dc.subject | Mycosis Fungoides/*chemistry/*virology | en |
| dc.subject | Proliferating Cell Nuclear Antigen/biosynthesis | en |
| dc.subject | Proto-Oncogene Proteins/biosynthesis | en |
| dc.subject | Proto-Oncogene Proteins c-bcl-2 | en |
| dc.subject | Proto-Oncogene Proteins c-myc/biosynthesis | en |
| dc.subject | Skin Neoplasms/*chemistry/*virology | en |
| dc.subject | Tumor Suppressor Protein p53/biosynthesis | en |
| dc.title | Mycosis fungoides: expression of C-myc p62 p53, bcl-2 and PCNA proteins and absence of association with Epstein-Barr virus | en |
| heal.type | journalArticle | - |
| heal.type.en | Journal article | en |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/7831152 | - |
| heal.language | en | - |
| heal.access | campus | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.publicationDate | 1994 | - |
| heal.abstract | The expression of C-myc p62, bcl-2, p53, PCNA and EBV-encoded LMP-1 proteins was studied by immunohistochemistry on paraffin-embedded skin specimens from 14 patients with early stage (premycotic erythema and second stage plaques) mycosis fungoides (MF), 21 patients with advanced stage MF (third stage plaques and tumors), 3 patients with Sezary's syndrome (SS) and 3 patients with pleomorphic medium and large cell cutaneous T-cell lymphomas (PML-CTCL). All 41 cases were also screened for the presence of EBV by using RNA in situ hybridization with EBER 1/2 oligonucleotides. Increased expression of C-myc p62, p53 and PCNA proteins was found in PML-CTCL and advanced stages of MF as compared to early stages of MF. These results suggest a relationship between levels of C-myc p62, p53 and PCNA proteins and aggressiveness of the cutaneous T-cell lymphomas. Furthermore, C-myc p62 and bcl-2 proteins were found to be frequently coexpressed in the present series. In view of the background information from in vitro findings and animal models that cooperation of C-myc and bcl-2 is important for lymphomagenesis, our results suggest that coexpression of these oncogenes may be implicated in the pathogenesis and/or the progression of cutaneous T-cell lymphomas. Neither LMP-1 expression nor EBV EBER l/2 transcripts were detected in our series suggesting that EBV is not involved in the pathogenesis of cutaneous T-cell lymphomas. | en |
| heal.journalName | Pathol Res Pract | en |
| heal.journalType | peer-reviewed | - |
| heal.fullTextAvailability | TRUE | - |
| Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ | |
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