Myelination process in preterm subjects with periventricular leucomalacia assessed by magnetization transfer ratio (Journal article)

Xydis, V./ Astrakas, L./ Drougia, A./ Gassias, D./ Andronikou, S./ Argyropoulou, M.

BACKGROUND: Magnetization transfer imaging assesses the myelination status of the brain. OBJECTIVES: To study the progress of myelination in children with periventricular leucomalacia (PVL) by measuring the magnetization transfer ratio (MTR) and to compare the MTR values with normal values. MATERIALS AND METHODS: Brain MTR in 28 PVL subjects (16 males, 12 females, gestational age 30.7+/-2.5 weeks, corrected age 3.1+/-2.9 years) was measured using a 3D gradient echo sequence (TR/TE 32/8 ms, flip angle 60 degrees, 4 mm/2 mm overlapping sections) without and with magnetization transfer prepulse and compared with normal values for preterm subjects. RESULTS: MTR of white-matter structures followed a monoexponential function model (y=A-B*exp(-x/C)) while the thalamus and caudate nucleus had a poor goodness of fit. MTR of the splenium of the corpus callosum reached a final value lower than normal (0.67 versus 0.70) at a younger age [t(99%) at 10.32 versus 18.90 months; P<0.05]. MTR of the normal-appearing occipital white matter and of the genu of the corpus callosum reached a normal final MTR but at a younger age than normal preterm infants [t(99%) at 8.51 versus 14.50 months and 12.51 versus 20.85 months, respectively]. CONCLUSION: In PVL subjects, myelination of the splenium is characterized by early arrest and deficient maturation. Accelerated myelination in unaffected white matter might suggest a compensatory process of reorganization.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: Child, Preschool,Contrast Media,Female,Gestational Age,Humans,Imaging, Three-Dimensional,Infant,Infant, Newborn,Infant, Premature,Leukomalacia, Periventricular/*pathology,Magnetic Resonance Imaging/*methods,Male,Reference Values,Regression Analysis,Retrospective Studies
ISSN: 0301-0449
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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