Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/19833
Full metadata record
DC FieldValueLanguage
dc.contributor.authorDouzinas, E. E.en
dc.contributor.authorPitaridis, M. T.en
dc.contributor.authorPatsouris, E.en
dc.contributor.authorKollias, S.en
dc.contributor.authorBoursinos, V.en
dc.contributor.authorKarmpaliotis, D. I.en
dc.contributor.authorGratsias, Y.en
dc.contributor.authorEvangelou, E.en
dc.contributor.authorPapalois, A.en
dc.contributor.authorKonstantinidou, A. E.en
dc.contributor.authorRoussos, C.en
dc.date.accessioned2015-11-24T19:02:46Z-
dc.date.available2015-11-24T19:02:46Z-
dc.identifier.issn0090-3493-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/19833-
dc.rightsDefault Licence-
dc.subjectAnimalsen
dc.subjectDisease Models, Animalen
dc.subjectHemodynamicsen
dc.subjectIleum/blood supplyen
dc.subjectIntestinal Mucosa/blood supplyen
dc.subjectMaleen
dc.subjectMyocardial Ischemia/*physiopathologyen
dc.subjectOxygen Consumptionen
dc.subjectRandom Allocationen
dc.subjectReperfusionen
dc.subjectReperfusion Injury/*physiopathologyen
dc.subjectShock/*physiopathologyen
dc.subjectSwineen
dc.titleMyocardial ischemia in intestinal postischemic shock: the effect of hypoxemic reperfusionen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.primary10.1097/01.CCM.0000080488.30157.D8-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/12973178-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate2003-
heal.abstractOBJECTIVE: The circulatory shock following intestinal ischemia-reperfusion injury has been attributed to hypovolemia. The purpose of the current study is to clarify the pathophysiology of this type of shock and to test the hypothesis that hypoxemic compared with normoxemic reperfusion improves hemodynamics. DESIGN: Randomized animal study. SETTING: Medical school laboratory. SUBJECTS: Twenty-one pigs. INTERVENTIONS: Pigs were subjected to 120 mins of intestinal ischemia by clamping the superior mesenteric artery. Upon declamping, the animals were randomized into two groups: a group that received hypoxemic reperfusion (HR group, n = 8) with a PaO2 = 30-35 and a control group reperfused with PaO2 = 100 mm Hg (control group, n = 13). MEASUREMENTS AND MAIN RESULTS: Measurements included mean arterial pressure, cardiac index, pulmonary artery occlusion pressure, and requirements for fluids and epinephrine. Biopsies from the terminal ileal mucosa were taken for malondialdehyde measurements at baseline, at 120 mins of ischemia, and at 30 and 60 mins of reperfusion. A piece of left ventricle was obtained after 120 mins of reperfusion for histologic studies. Five of 13 animals of the control group died in intractable shock; no animal of the HR group died (p =.11). The decrease in the mean arterial pressure during reperfusion was more pronounced in the control group (p <.008) despite the larger doses of epinephrine administered, compared with the HR group (p <.02). During reperfusion, both groups exhibited a decrease in cardiac index; this was more pronounced in the control group (p =.0007). Pulmonary artery occlusion pressure increased during reperfusion in both groups and was more pronounced in the control group (p =.04 at 60 mins). Although mixed venous blood oxygen saturation of the control animals was higher at 30 mins of reperfusion (p =.005), it declined after 60 mins and became lower than that of HR animals at the end of reperfusion (p <.02). The myocardial histopathologic injury score was higher in the control group (2.0 +/- 0.69 and 3.4 +/- 0.89 for the HR and control groups, respectively; p <.03). The concentrations of intestinal mucosa malondialdehyde were significantly higher in the control group at 60 mins of reperfusion (p <.03). CONCLUSIONS: Acute myocardial ischemia and left heart failure significantly contribute to the circulatory shock that follows intestinal ischemia/reperfusion injury and are attenuated by hypoxemic reperfusion.en
heal.journalNameCrit Care Meden
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ

Files in This Item:
There are no files associated with this item.


This item is licensed under a Creative Commons License Creative Commons