Turner's syndrome with concomitant hypopituitarism: case report (Journal article)

Efstathiadou, Z./ Tsatsoulis, A.


The unique case of a young woman with concomitant pituitary insufficiency and gonadal dysgenesis due to Turner's syndrome is described. At the age of 17 years, when first examined elsewhere, this patient was prepubertal and short and a diagnosis of growth hormone deficiency was made. One year later, while on growth hormone (GH) substitution, thyrotrophin deficiency and hypogonadotrophic hypogonadism were confirmed and thyroxine and sex steroid substitution therapy was initiated. Upon evaluation in our clinic, at the age of 30 years, the low final height achieved with the GH substitution therapy, a number of clinical characteristics and the absence of ovarian tissue on ultrasound led to examination of the patient's karyotype, which revealed concurrent gonadal dysgenesis due to Turner's syndrome. This case illustrates that the co-existence of primary and secondary hypogonadism may obscure and delay the diagnosis of Turner's syndrome, a diagnosis which alters the counselling of the patient from the reproductive perspective.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: Adult,Body Height,Bone Development,Drug Therapy, Combination,Estrogens/therapeutic use,Female,Humans,Hypopituitarism/*complications,Progestins/therapeutic use,Thyroxine/therapeutic use,Turner Syndrome/*complications/*diagnosis/drug therapy/pathology
URI: http://olympias.lib.uoi.gr/jspui/handle/123456789/19832
ISSN: 0268-1161
Link: http://www.ncbi.nlm.nih.gov/pubmed/11056139
http://humrep.oxfordjournals.org/content/15/11/2388.full.pdf
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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